Conducting night cardiorespiratory monitoring in patients with chronic obstructive pulmonary disease allows us to identify 4 clinical and pathogenetic variants of breathing during the night hours. The course of chronic obstructive pulmonary disease without obstructive sleep apnea syndrome in older patients with a long history of the disease, severe obstructive disorders and pulmonary hypertension can lead to nocturnal hypoxemia and poor quality of night sleep.. Patients with chronic obstructive pulmonary disease with obstructive sleep apnea syndrome and persistent nocturnal hypoxemia against the background of effective sipap therapy need additional low-flow oxygenotherapy during the night hours. Patients with severe chronic obstructive pulmonary disease without obstructive sleep apnea need low-flow oxygen therapy at night.