Articles
| Open Access |
DOI:
https://doi.org/10.37547/ijmscr/Volume04Issue06-06
HEART RHYTHM DISTURBANCES IN CONNECTIVE TISSUE DYSPLASIA
Shodikulova Gulandom Zikriyayevna , Professor, Samarkand State Medical University, Samarkand, Uzbekistan Gulomov Jahongir Ibrokhimovich , Assistant, Samarkand State Medical University, Samarkand, Uzbekistan Samatov Dilshod Karimovich , Assistant, Samarkand State Medical University, Samarkand, Uzbekistan Khasanov Oybek Gafurovich , Assistant, Samarkand State Medical University, Samarkand, UzbekistanAbstract
The article discusses the association between connective tissue dysplasia (CTD) and arrhythmias, particularly focusing on mitral valve prolapse as a potential risk factor for life-threatening ventricular arrhythmias and sudden cardiac death. Various studies emphasize the structural and mechanical abnormalities in the heart that contribute to arrhythmogenic phenotypes in CTD patients, such as fibrosis, mitral annular disjunction, and accessory chordae. Additionally, the text explores the role of autoantibodies, cardiac remodeling, and autoimmune processes in mediating rhythm disturbances and cardiac complications in CTD. The importance of ECG analysis, neural networks, and stress tests in detecting and monitoring arrhythmias in CTD patients is highlighted. The research underscores the significance of understanding the morphological basis and pathophysiological mechanisms of arrhythmias in CTD patients to improve therapeutic strategies and enhance patient outcomes.
Keywords
Connective tissue (CT), Connective tissue dysplasia (CTD), Mechanoelectric feedback (MEFE)
References
Пулатов У. С., Суюнов А. Ф. ПОЛИМОРФИЗМ ГАПТОГЛОБИНА У БОЛЬНЫХ С РЕВМАТОИДНЫМ АРТИРОМ //" Conference on Universal Science Research 2023". – 2023. – Т. 1. – №. 2. – С. 120-123.
Пулатов У., Нематуллаев Ж., Шопулотова З. ОСТРЫЕ РЕСПИРАТОРНЫЕ ВИРУСНЫЕ ИНФЕКЦИИ: СИМПТОМЫ, ЛЕЧЕНИЕ И ПРОФИЛАКТИКА //Евразийский журнал медицинских и естественных наук. – 2024. – Т. 4. – №. 5. – С. 269-273.
Пулатов У. С. и др. ОСОБЕННОСТИ ЛЕЧЕНИЯ ПРИ ХПН //INNOVATIVE DEVELOPMENTS AND RESEARCH IN EDUCATION. – 2023. – Т. 2. – №. 23. – С. 303-305.
Шодикулова Г. З. и др. СОВРЕМЕННЫЙ ВЗГЛЯД НА ПРОБЛЕМУ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ У БОЛЬНЫХ С ПОДАГРОЙ И БЕССИМПТОМНОЙ ГИПЕРУРИКЕМИЕЙ //Journal of cardiorespiratory research. – 2023. – Т. 1. – №. 1. – С. 28-33.
Шодикулова Г. З., Мирзаев О. В., Саматов Д. К. РАСПРОСТРАНЕННОСТЬ И КЛИНИКО-ГЕНЕТИЧЕСКИЕ ОСОБЕННОСТИ ДИСПЛАЗИИ СОЕДИНИТЕЛЬНОЙ ТКАНИ У ЛИЦ УЗБЕКСКОЙ ПОПУЛЯЦИИ //Journal of cardiorespiratory research. – 2023. – Т. 1. – №. 1. – С. 94-98.
Glesby M.J. Association and systemic abnormalities of connective tissue / M.J. Glesby, R.E. Pyeritz // JAMA. - 1989. - Vol. 262. - P. 523-528.
National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Care Services; Committee on Selected Heritable Disorders of Connective Tissue and Disability; Wedge RA, Cartaxo T, Spicer CM, et al., editors. Selected Heritable Disorders of Connective Tissue and Disability. Washington (DC): National Academies Press (US); 2022 Jul 8. 2, Overview of Hereditary Disorders of Connective Tissue. Available from: https://www.ncbi.nlm.nih.gov/books/NBK584965/
Loginova, E. & Kirh, E. & Nechaeva, G. & Martynov, A. & Druk, Inna & Semenkin, A. & Dakuko, A.. (2022). Role of genetic research in the prevention of life-threatening rhythm and cardiac conduction disorders in young people. Russian Journal of Cardiology. 27. 4991. 10.15829/1560-4071-2022-4991.
Pérez-Riera AR, Barbosa-Barros R, de Rezende Barbosa MPC, Daminello-Raimundo R, de Lucca AA Jr, de Abreu LC. Catecholaminergic polymorphic ventricular tachycardia, an update. Ann Noninvasive Electrocardiol. 2018 Jul;23(4):e12512. doi: 10.1111/anec.12512. Epub 2017 Oct 19. PMID: 29048771; PMCID: PMC6931575.
Larraitz Gaztañaga, Francis E. Marchlinski, Brian P. Betensky. Mechanisms of Cardiac Arrhythmias // Revista Española de Cardiología (English Edition), Vol. 65, Issue 2, 2012, P.174-185, ISSN 1885-5857, https://doi.org/10.1016/j.rec.2011.09.020.
Hazim A, Belhamadia Y, Dubljevic S. A Simulation Study of the Role of Mechanical Stretch in Arrhythmogenesis during Cardiac Alternans. Biophys J. 2021 Jan 5;120(1):109-121. doi: 10.1016/j.bpj.2020.11.018. Epub 2020 Nov 26. PMID: 33248131; PMCID: PMC7820729.
Fernández-Friera L, Salguero R, Vannini L, Argüelles AF, Arribas F, Solís J. Mechanistic insights of the left ventricle structure and fibrosis in the arrhythmogenic mitral valve prolapse. Glob Cardiol Sci Pract. 2018 Mar 14;2018(1):4. doi: 10.21542/gcsp.2018.4. PMID: 29644231; PMCID: PMC5857061.
Nagata Y, Bertrand PB, Baliyan V, Kochav J, Kagan RD, Ujka K, Alfraidi H, van Kampen A, Morningstar JE, Dal-Bianco JP, Melnitchouk S, Holmvang G, Borger MA, Moore R, Hua L, Sultana R, Calle PV, Yum B, Guerrero JL, Neilan TG, Picard MH, Kim J, Delling FN, Hung J, Norris RA, Weinsaft JW, Levine RA. Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse. Circ Cardiovasc Imaging. 2023 Apr;16(4):e014963. doi: 10.1161/CIRCIMAGING.122.014963. Epub 2023 Apr 18. PMID: 37071717; PMCID: PMC10108844.
Wu S, Siegel RJ. Mitral annular disjunction: A case series and review of the literature. Front Cardiovasc Med. 2022 Aug 12;9:976066. doi: 10.3389/fcvm.2022.976066. PMID: 36035903; PMCID: PMC9411994..
Tison GH, Abreau S, Barrios J, Lim LJ, Yang M, Crudo V, Shah DJ, Nguyen T, Hu G, Dixit S, Nah G, Arya F, Bibby D, Lee Y, Delling FN. Identifying Mitral Valve Prolapse at Risk for Arrhythmias and Fibrosis From Electrocardiograms Using Deep Learning. JACC Adv. 2023 Aug;2(6):100446. doi: 10.1016/j.jacadv.2023.100446. Epub 2023 Aug 5. PMID: 37936601; PMCID: PMC10629907.
Velthuis S, Senden PJ. Left ventricular false tendons. Neth Heart J. 2021 Sep;29(9):419-422. doi: 10.1007/s12471-021-01592-5. Epub 2021 Jul 7. PMID: 34232482; PMCID: PMC8397804.
Naganuma T, Mori H, Tsutsui K, Yamazaki H, Kato R. Premature ventricular contraction originating from a papillary muscle-chordae transition inside the left ventricle. J Arrhythm. 2022 Aug 8;38(5):809-812. doi: 10.1002/joa3.12765. PMID: 36237863; PMCID: PMC9535745
Franz M.R. Mechano-electrical feedback underlying arrhythmias: the atrial fibrillation case / M.R. Franz, F. Bode // Prog. Biophys. Md. Biology. - 2003. - Vol. 82, №3. - P. 163-174.
Podrid Ph.J. Handbook of cardiac arrhythmia / Ph.J. Podrid, P.R. Kowey. - Baltimore, Williams & Wilkins, 1996. - 459 p.
Petras A, Gsell MAF, Augustin CM, Rodriguez-Padilla J, Jung A, Strocchi M, Prinzen FW, Niederer SA, Plank G, Vigmond EJ. Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology. Comput Biol Med. 2023 Apr;156:106696. doi: 10.1016/j.compbiomed.2023.106696. Epub 2023 Feb 24. PMID: 36870172; PMCID: PMC10040614.
Shodikulova G. Z. et al. The Correlation among Osteoporosis, Calcium-Phosphore Metabolism and Clinical Symptoms of Main Disease in Patients with Rheumatoid Arthritis //Annals of the Romanian Society for Cell Biology. – 2021. – С. 4185-4190.
Article Statistics
Copyright License
Copyright (c) 2024 Shodikulova Gulandom Zikriyayevna, Gulomov Jahongir Ibrokhimovich, Samatov Dilshod Karimovich, Khasanov Oybek Gafurovich
This work is licensed under a Creative Commons Attribution 4.0 International License.