SIGNIFICANCE OF TLR6 GENE IN COMPLICATIONS OF MYELOMA DISEASE
Abstract
This article discusses the significance of the TLR6 gene in the complications of myeloma, a malignant tumor disease that develops from bone marrow plasma cells. Studies have shown that increased TLR6 gene expression in myeloma patients is associated with more severe complications and a worse disease prognosis. This may be due to increased inflammation in the body and increased activation of the immune system. Understanding the role of the TLR6 gene may help develop new approaches to the diagnosis, treatment and prevention of myeloma.
Keywords
TLR6 gene, complications, prognosisHow to Cite
References
Bohnert V, Schäfer C, Müller-Tidow C, et al. Toll-like receptors in normal and malignant hematopoiesis. Curr Pharm Des. 2006;12(32):4219-4232. doi:10.2174/138161206779010392
Vacca A, Ribatti D, Presta M, et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood. 1999;93(9):3064-3073.
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11(5):373-384. doi:10.1038/ni.1863
Vacca A, Ria R, Reale A, et al. TLR gene expression profile in human multiple myeloma cells: down-regulation of TLR3 expression. Cancer Immunol Immunother. 2006;55(7):910-920. doi:10.1007/s00262-005-0079-1
Botta C, Gulla A, Correale P, Tagliaferri P, Tassone P. Myeloma cells suppress osteoblasts through sclerostin secretion. Blood Cancer J. 2011;1(6):e27. doi:10.1038/bcj.2011.26
License
Copyright (c) 2023 Kakhkharova N.Kh., Kayumov A.A.
This work is licensed under a Creative Commons Attribution 4.0 International License.