Cefetamet Sodium, a third-generation cephalosporin antibiotic, has gained significant attention due to its efficacy against a broad spectrum of bacterial infections. However, existing synthesis methods often present challenges such as low yields, complex procedures, and environmental concerns. This study presents a comprehensive approach to process development aimed at optimizing the synthesis of Cefetamet Sodium. We explored novel pathways, employing innovative synthetic routes and green chemistry principles to enhance yield and reduce waste. Key parameters including reaction conditions, catalyst selection, and purification techniques were systematically evaluated to establish an efficient and reproducible process. The results demonstrated significant improvements in overall yield and purity of the final product. Additionally, the developed process was assessed for scalability, feasibility, and economic viability. This research contributes valuable insights into the synthesis of Cefetamet Sodium, paving the way for more sustainable production practices in the pharmaceutical industry.

Cefetamet Sodium, Antibiotic synthesis, Process development

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Xian Yang1,Long Enwu1,Yuan Haoyu2(1.Sichuan Provincial People's Hospital,Sichuan Academy of Medical Science,Chengdu,Sichuan,China 610072;2.416 Hospital of Nuclear Industry Ministry,Chengdu,Sichuan,China 610051); Determination of Cefetamet Pivoxil Hydrochloride Capsules by RP-HPLC[J];China Pharmaceuticals;2010-07

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