Uranium contamination in soil poses significant environmental and ecological risks, affecting microbial communities and their functions. This study explores the resilience of bacterial species in uranium-contaminated environments by identifying and characterizing affected microbial populations. Soil samples from uranium-impacted sites were analyzed using culture-dependent and molecular techniques to assess bacterial diversity, resistance mechanisms, and potential bioremediation capabilities. The results indicate the presence of uranium-tolerant bacteria, including species with metal-resistant genes and bioaccumulation properties. Understanding these adaptive mechanisms provides insights into microbial responses to heavy metal stress and informs bioremediation strategies for uranium-contaminated ecosystems.