Articles | Open Access | DOI: https://doi.org/10.37547/ajahi/Volume03Issue04-06

ASSESSMENT OF THE ANTIBACTERIAL AND ANTI-FUNGAL ACTIVITY OF THE BIOLOGICALLY ACTIVE SUBSTANCE PREPARED FROM LOCAL PLANT EXTRACTS

Bakhramova N.N. , Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan
Abidova R.M. , Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan
Ergashov O.I. , Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan
Boymurodov B.T. , Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan
Qalandarova F.S. , Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan

Abstract

In this research work presented, the results obtained in the study of the general pharmacological properties of plant damalamari with anti-anemia activity, in particular, the effect on the an analysis of the literature on antimicrobial and pathogenic fungal activity was carried out. All the studies carried out were carried out in different animals, which serves to increase the reliability level and efficiency values of these experiments. Thus, a fresh decoction, developed on the basis of local medicinal plants, is less poisonous, it is from local tickling, cumulative and allergic effects. At the same time, the possibilities of applying the studied extract damalam against microbes and pathogenic fungi mainly in solution are being studied. The overall safety or non-toxicity of each biologically active substance is important for this reason, in this article we did not dwell in detail on its main activity.

Keywords

General pharmacology plant extract, pathogenic fungal activity, skin resorption

References

Cotoraci C, Ciceu A, Sasu A, Hermenean A. Natural Antioxidants in Anemia Treatment. Int J Mol Sci. 2021 Feb 13;22(4):1883. doi: 10.3390/ijms22041883.

Muhammad ABDULLAH, Shahid MAHMOOD, Zaheer AHMED. Evaluation of anti anemic prospective of natural iron sources in lactating women- an ignored important segment of Pakistani population. Food Sci. Technol, Campinas, 41(2): 453-460, Apr.-June 2021. DOI: https://doi.org/10.1590/fst.05020

Dukhnitskyі V., Derkach, I., Derkach, S., Fritsky, I., & Plutenko, M. (2020). Antianemic effect of preparations of iron in pigs. Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, (4 (51), 46-51. https://doi.org/10.32845/bsnau.vet.2020.4.7

Муҳаммаджонов Баҳриддин Баҳромжон ўғли, Ҳамроев Толмас Толибович, Ғаниев Рустам Равшан ўғли, Нурметова Юлдуз Балтаевна, Мадвалиев Баходиржон Толибжон ўғли, Илмияминов Отабек Алишер ўғли. (2022). Доривор хусусиятга эга ўсимликлар йиғмасининг анемияга қарши фаоллигини баҳолаш. Eurasian journal of medical and natural sciences, 2(11), 322–327. https://doi.org/10.5281/zenodo.7248323

Nabiev U.N., Nazarkulova Sh.U., Xasanova G.S., Rakhimzoda T.E. (2023). Evaluation of the effect of harvesting plants with high biological activity on the central and peripheral nervous system. Eurasian journal of medical and natural sciences, 3(1), 28–33. https://doi.org/10.5281/zenodo.7559644

McLean E., Cogswell M., Egli I., Wojdyla D., de Benoist B. Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005. Publ. Health Nutr. 2009;12:444–454. doi: 10.1017/S1368980008002401.

Figueiredo A.C.M.G., Gomes-Filho I.S., Silva R.B., Pereira P.P.S., Mata F.A.F.D., Lyrio A.O., Souza E.S., Cruz S.S., Pereira M.G. Maternal anemia and low birth weight: A systematic review and meta-analysis. Nutrients. 2018;10:601. doi: 10.3390/nu10050601.

Haider B.A., Olofin I., Wang M., Spiegelman D., Ezzati M., Fawzi W.W. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: Systematic review and meta-analysis. BMJ. 2013;346:f3443. doi: 10.1136/bmj.f3443.

Rahman M.M., Abe S.K., Rahman M.S., Kanda M., Narita S., Bilano V., Ota E., Gilmour S., Shibuya K. Maternal anemia and risk of adverse birth and health outcomes in low- and middle-income countries: Systematic review and meta-analysis. Am. J. Clin. Nutr. 2016;103:495–504. doi: 10.3945/ajcn.115.107896.

McCann J.C., Ames B.N. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am. J. Clin. Nutr. 2007;85:931–945. doi: 10.1093/ajcn/85.4.931.

Hillman R.S., Adult K.A., Leporrier M., Rinder H.M. Clinical approach to anemia. In: Hillman R.S., Ault K.A., editors. Hematology in Clinical Practice. McGraw-Hill; New York, NY, USA: 2001. p. 29.

GBD 2015 Disease and Injury Incidence and Prevalence Collaborators Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1545–1602. doi: 10.1016/S0140-6736(16)31678-6.

Маматкулова Н.М., Саноев З.И., Кҳамроев Т.Т., Кҳидйрова Н.К., Махмудова Д.М. Изучение острой токсичности и биологическая активност сухого экстракта цветков gossypium hirsutum l. SOI:1.1/TAS DOI:10.15863/TAS International Scientific Journal Theoretical & Applied Science p-ISSN: 2308-4944 (print) e-ISSN: 2409-0085 (online) Year: 2021 Issue: 10 Volume: 102 Published:30.10.2021http://T Science.org.

Mirzaev Yu.R., Khamraev T.T., Ruzimov E.M., Khamdamov B.N., Abduazimov B.B., Adizov Sh.M., Elmurodov B.J., Yuldashev P.H.. (2022). Study of the effect of alkaloids isolated from the vinca erecta plant on cardiac activity under experimental conditions. Eurasian journal of medical and natural sciences, 2(11), 250–255. https://doi.org/10.5281/zenodo.7220861

Mirzaev Yu.R., Khamroev T.T., Ruzimov E.M., Khamdamov B.N., Abduazimov B.B., Adizov Sh.M., Yuldashev P.Kh., & Elmuradov B.J. (2022). Comparative assessment of acute toxicity of vincanin hydrochloride derivatives in research conditions. International Journal of Medical Sciences And Clinical Research, 2(10), 9–15. https://doi.org/10.37547/ijmscr/Volume02Issue10-03

Yu.R. Mirzаev, T.T. Khamraev, E.M. Ruzimov, Sh.M. Adizov, B.B. Abduazimov, B.N. Khandamov, B.J. Elmurodov, P.H. Yuldashev. (2022). Toxicological characteristics of vincanin hydrochloride and its derivatives in an experimental condition. Eurasian journal of academic research, 2(11), 1027–1033. https://doi.org/10.5281/zenodo.7244593

Yu.R. Mirzaev, T.T. Khamroev, E.M. Ruzimov, B.N. Khamdamov, B.B. Abduazimov, Sh.M. Adizov, P.Kh. Yuldashev, & B.J. Elmuradov. (2022). Evaluation of the effect of vincanin hydrochloride and its derivatives on blood pressure and respiration under experimental conditions. Oriental Journal of Medicine and Pharmacology, 2(04), 1–11. https://doi.org/10.37547/supsci-ojmp-02-04-01

Yu. R. Mirzaev, T. T. Khamroev, E. M. Ruzimov, B. N. Khandamov, & Sh. M. Adizov. (2022). Evaluation of the Effect on the Nervous System of Substances with an Alkaloid Structure Having Antitumor Activity. Journal Healthcare Treatment Development(JHTD) ISSN : 2799-1148, 2(06), 6–10. Retrieved from http://journal.hmjournals.com/index.php/JHTD/article/view/1577

Aripov A.N, Akhunjanova L.L, Khamroev T.T, Aripov Abdumalik Nigmatovich, Akhunjanova Lola Lazizovna, & Khamroev Tolmas Tolibovich. (2022). Differential Analysis of Chronic Toxic Hepatitis Caused by The Introduction of Heliotrin Solution in Various Ways. Texas Journal of Medical Science, 4, 58–62. Retrieved from https://zienjournals.com/index.php/tjms/article/view/670

Арипов А.Н., Арипов О.А., Ахунджанова Л.Л., Набиев А.Ў., Нишанбаев С.З., Набиева Д.А., Hамроев Т.Т. Тажриба шароитида сафорофлавонолозиднинг гепатотроп фаоллигини ўрганиш. Oriental Journal of Medicine and Pharmacology, 2(02), 55–64. https://doi.org/10.37547/supsci-ojmp-02-02-07

Aripov A.N., Aripov O.A., Akhunjanova L.L., Nabiev A.O., Nabieva D.A., & Khamroev T.T. (2022). Study the antifibrous efficacy of plant proanthocyanidin in rats with chronic heliotrine liver damage. Frontline Medical Sciences and Pharmaceutical Journal, 2(05), 16–25. https://doi.org/10.37547/medical-fmspj-02-05-03.

Aripov A.N., Aripov O.A., Akhunjanova L.L., Nabiev A.O., Nabieva D.A., & Khamroev T.T. (2022). Study the antifibrous efficacy of plant proanthocyanidin in rats with chronic heliotrine liver damage. Frontline Medical Sciences and Pharmaceutical Journal, 2(05), 16–25. https://doi.org/10.37547/medical-fmspj-02-05-03.

Aripov A.N., Aripov O.A., Akhundjanova L.L., Nabiev A.U., Nabieva D.A., & Khamroev T.T. (2022). Study the effect of yantacin on some indicators of cellular renewal and on the level of protein expression on rat hepatocytes in chronic heliotrine liver damage. International Journal of Medical Sciences And Clinical Research, 2(05), 06–13. https://doi.org/10.37547/ijmscr/Volume02Issue05-02.

Т.Т.Ҳамроев, Н.М.Маматқулова, П.А.Нурмахмадова, С.З.Рашидов, И.Т.Абдиназаров, С.Д.Раҳимбоев, Н.Қ.Хидирова, У.М.Якубов. (2022). Adonis turkestanica ўсимлигининг экстракция жараёнида ҳосил бўлган қолдиқ моддаларнинг ўткир заҳарлилиги ва биологик фаоллигини скрининг тадқиқотларда ўрганиш. Eurasian journal of academic research, 2(12), 447–454. https://doi.org/10.5281/zenodo.7332870

Т.Т. Ҳамроев, Н.М. Маматқулова, З.И. Саноев, С.З. Рашидов, И.Т. Абдиназаров, П.А. Нурмахмадова, Н.Қ. Хидирова, У.М. Якубов. (2022). Adonis turkestanica ўсимлигининг экстракция жараёнида ҳосил бўлган қолдиқ моддаларнинг анксиолитик фаоллигини скрининг тадқиқотларда ўрганиш. Eurasian journal of medical and natural sciences, 2(12), 146–152. https://doi.org/10.5281/zenodo.7332882

Muhammadjonov Bakhriddin Bakhromjon ogli, Ganiev Rustam Ravshan ogli, Nurmetova Yulduz Baltaevna, Madvaliev Baxodirjon Tolibjon ogli, Ilmiyaminov Otabek Alisher ogli, & Khamroev Tolmas Tolibovich. (2022). Evaluation of the Effect of Collecting Plants with Medicinal Properties on the Course of Hemolytic Anemia in the Study Conditions. International journal of health systems and medical sciences, 1(5), 45-51. Retrieved from http://inter-publishing.com/index.php/IJHSMS/article/view/338

Миронов А.Н.Руководство по проведению доклинических исследований лекарственных средств. Част первая. — М.: Гриф и К, 2012. — 944 с.

Poimenidou, S. V. et al. Effect of single or combined chemical and natural antimicrobial interventions on Escherichia coli O157:H7, total microbiota and color of packaged spinach and lettuce. Int. J. Food Microbiol. 220, 6–18 (2016).

Ashraf A. Mostafa , Abdulaziz A. Al-Askar , Khalid S. Almaary , Turki M. Dawoud , Essam N. Sholkamy , Marwah M. Bakri. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi Journal of Biological Sciences. Volume 25, Issue 2, February 2018, Pages 361-366 https://doi.org/10.1016/j.sjbs.2017.02.004

Article Statistics

Copyright License

Download Citations

How to Cite

Bakhramova N.N., Abidova R.M., Ergashov O.I., Boymurodov B.T., & Qalandarova F.S. (2023). ASSESSMENT OF THE ANTIBACTERIAL AND ANTI-FUNGAL ACTIVITY OF THE BIOLOGICALLY ACTIVE SUBSTANCE PREPARED FROM LOCAL PLANT EXTRACTS. American Journal Of Agriculture And Horticulture Innovations, 3(04), 29–36. https://doi.org/10.37547/ajahi/Volume03Issue04-06