Objective: to establish the main causes and outcomes of preterm pregnancy in the period of 22-276 weeks of gestation. Material and methods. A retrospective study of 100 cases of very early preterm birth (VEРB) was conducted. Results. VEРB more often occurred at the age of 20-29 years in multipregnant women whose anamnesis was aggravated by miscarriage and prematurity, perinatal losses. A high risk of developing pregnancy complications leading to VEРB was IDA (78.0%), pathology of the urinary tract (45.0%), and hypertension (31.0%). The survival rate of newborns up to 25 weeks of gestation was 3.7%, then it increases and by the 27th week it reaches 53.3% (M±m=31.9±4.4%).

Very early preterm birth, causes, complications, perinatal outcomes.

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Dolgushina V.F., Kurnosenko I.V., Astashkina M.V. Intrauterine infection during pregnancy. Akusherstvo i Ginekologiya (Obstetrics and Gynecology). 2021; (6): 41–46.[in Rush.]

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Ruzieva N.Kh., Djabbarova L.A., Djabbarova Yu.K. Causes and approaches to reducing preterm birth using international strategies. RR-HEALTH Journal. Andijan. 2021; 1(9): 14–18.[in Rush.]

Yuldasheva N.O., Musabayeva A.M., Saparaliyeva A.Kh., Absalyamova M.M., Edilova K.B., Sariyeva R.S., Izbasarova R.S. Preterm birth: analysis of causes and perinatal outcomes. Vestnik KazNMU. 2017; (3): 15–23.[in Rush.]

Di Renzo D.C., Cabero Roura L., Facchinetti F.[et al.]. Preterm labor and birth management: recommendations from the European Association of Perinatal Medicine.The journal of maternal-fetal & neonatal medicine. Med. 2017. Vol. 30, № 17. P. 2011–2030.

Eric O Ohuma, Ann-Beth Moller, Ellen Bradley , Samuel Chakwera, Laith Hussain-Alkhateeb. National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis// Lancet. 2023 Oct 7;402(10409):1261-1271. doi: 10.1016/S0140-6736(23)00878-4

Neonatal mortality data //https://data.unicef.org/resources/dataset/neonatal-mortality-data/January 2023.

Walani SR Global burden of preterm birth - 10 June 2020 - International https://doi.org/10.1002/ijgo.13195