The aim of this study was to identify risk factors for the development of cardiovascular disorders and to improve the algorithm for their early diagnosis in children with type 1 diabetes mellitus following COVID-19 infection. This was based on a comprehensive assessment of metabolic, immuno-inflammatory, angiogenic, and functional indicators of the cardiovascular system. The study included 254 children aged 7 to 18 years with type 1 diabetes mellitus who received inpatient treatment at the pediatric department of the Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Yo.Kh. Turakulov from 2020 to 2023. The examination was conducted 6 months after COVID-19 infection. The main group consisted of 102 children, divided into 2 subgroups: the 1st subgroup - children with cardiovascular disorders and diabetic cardiovascular autonomic neuropathy (DCAN) (n=28), the 2nd subgroup - children with DCAN (n=74). The comparison group comprised 152 children without cardiovascular disorders and DCAN, while the control group included 30 generally healthy children who had COVID-19 infection without diabetes mellitus. The identified relationships confirm that metabolic decompensation and post-infectious inflammation play a key role in the development of early functional disorders of the myocardium and vascular regulation. This can be considered one of the leading mechanisms for the formation of cardiovascular neuropathy in children with type 1 diabetes mellitus in the post-COVID period.

Type 1 diabetes mellitus, children, COVID-19

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