The adolescent period is a fundamental stage in the formation of reproductive health and the reproductive potential of women of fertile age. Consequently, an in-depth study of adolescent girls during puberty and the identification of delayed puberty (DP), taking into account possible etiopathogenetic factors of its development, will allow for the development of predictive methods and scientifically substantiate the identification of risk groups, thereby contributing to the preservation of reproductive potential. The objective of this study was to develop a scientifically based, comprehensive approach to the diagnosis and prediction of DP in adolescent girls, considering the functional state of the somatic and reproductive systems. At the screening stage for detecting DP, 115 adolescent girls (aged 14–18 years) from School No. 83 in Tashkent were enrolled. In the second stage, 48 girls were selected for the main group, along with 50 healthy adolescent girls (control group) who had no delays in pubertal development and presented with a normal menstrual cycle. A comprehensive analysis of the universal screening results established that the prevalence of delayed puberty (DP) among girls aged 14–18 years was 13.9% ± 0.9%; specifically, signs of Grade I DP were observed in 7.82% ± 1.9%, Grade II DP in 4.34% ± 1.5%, and Grade III DP in 1.73% ± 2.4% of cases. An integrated assessment of risk factors revealed that the most significant factors were a combination of a history of infectious diseases with acute and chronic tonsillitis (relative risk weight index R=2.0), the presence of thyroid pathology during puberty (R=2.04), mental and physical strain (R=1.82), age at menarche (R=1.79), and socioeconomic and living conditions (R=1.67). By calculating the total sum of R (ΣR) for all factors (18.49) and determining the sum of the maximum and minimum values of the prognostic coefficients, the boundaries of the risk ranges (Pmin and Pmax) for the development of DP in adolescent girls were established. Consequently, we have developed criteria for predicting delays in pubertal development, which ensure the identification of risk groups for the development of DP.

Adolescent girls, delayed puberty, prediction of delayed puberty

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