Articles | Open Access | DOI: https://doi.org/10.37547/ijmscr/Volume03Issue02-16

POLYCYSTIC OVARY SYNDROME: A MODERN VIEW ON THE PROBLEM

Jamolbek A. Djuraev , Tashkent Medical Academy, Uzbekistan
Abdurasul J. Botirov , Tashkent Medical Academy, Uzbekistan
Azizkhon Z. Shaumarov , Tashkent Medical Academy, Uzbekistan
Sabina Sodikova , Kimyo International University In Tashkent, Uzbekistan
Sabrina Kuddusova , Kimyo International University In Tashkent, Uzbekistan
Dilafruz Turabaeva , Kimyo International University In Tashkent, Uzbekistan
Mukhammadalieva Nurjakhon , Kimyo International University In Tashkent, Uzbekistan
Ambarjon Nurmetova , Kimyo International University In Tashkent, Uzbekistan

Abstract

The author of this article presents a modern understanding of the problem of polycystic ovary syndrome (PCOS). PCOS is a multifactorial, genetically determined pathological condition, in the pathogenesis of which an important role belongs to disorders of gonadotropic regulation, hyperandrogenism, insulin resistance, adipose tissue dysfunction and other factors. Obviously, PCOS is a socially significant gynecological pathology of early reproductive age, which requires optimization of the diagnosis and management of such patients from adolescence.

In adolescents, PCOS is diagnosed in the presence of clinical hyperandrogenism and an irregular menstrual cycle, while ultrasound criteria are not always reliable. For an individual approach and choice of treatment tactics, it is extremely important to verify the diagnosis of PCOS in a timely manner, determine the clinical phenotype and take into account the reproductive plans of the patient.

Keywords

Hyperandrogenism, anovulation, infertility

References

Savelyeva G., Sukhikh G., Serov V., Radzinskiy V., Manukhin I. (2019) Ginekologiya. Natsionalnoye rukovodstvo[Gynecology. National guideline]. Мoscow: GEOTAR-Media. (in Russian)

Teede H., Misso M., Costello M. (eds.) (2018) International evidence-based guideline for the assesstent and management of polycystic ovary syndrome.

Adamyan L., Andreyeva E., Absatarova Y., Grigoryan O., Dedov I., Melnichenko G., Suturina L., Filippov O., Sherementyeva E.,Chernukha G., Yarmolinskaya M. (2021) Sindrom polikistoznykh yaichnikov. Klinicheskiye rekomendatsii (protokol lecheniya)[Polycystic ovary syndrome. Clinical guidelines (treatment protocol)]. Мoscow. (in Russian)

Azziz R. (2016) PCOS in 2015: new insights into the genetics of polycystic ovary syndrome. Nat. Rev. Endocrinol.,vol. 12, no 2, pp. 74–75. doi: 10.1038/nrendo.2015.230.

Azziz R. (2016) PCOS in 2015: new insights into the genetics of polycystic ovary syndrome. Nat. Rev. Endocrinol.,vol. 12, no 2, pp. 74–75. doi: 10.1038/nrendo.2015.230.

Lerchbaum E., Schwetz V., Giuliani A., Obermayer-Pietsch B. (2014) Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women. Eur. J. Endocrinol.,vol. 170, no 5, pp. 727–739. doi: 10.1530/EJE-13-1035.

Panarina O., Rashidova M., Belenkaya L., Trofimova T., Sholokhov L. (2017) Sovremennyye predstavleniya o patogeneze sindroma polikistoznykh yaichnikov (obzor literatury) [Modern concepts of the pathogenesis of polycystic ovary syndrome (literature review)]. Acta Biomedica Scientifi ca,vol. 2, no 4, pp. 9–14.

Solopova A., Makatsariya A., Solopova A., Nikiforova O. (2017) Skleropolikistoznyye yaichniki: sovremennyy vzglyad na problemu [Sclerocystic ovaries: current approaches to the problem]. Obstetrics. Gynecology. Reproduction,vol. 11, no 2, pp. 60.

Guriyev T. (2010) Sindrom polikistoznykh yaichnikov [Polycystic ovarian syndrome]. Obstetrics, gynecology and reproduction,vol. 4, no 2, pp. 10–15.

Shestakova I., Ryabinkina T. (2015) SPKYa: novyy vzglyad na problemu. Mnogoobraziye simptomov. differentsialnaya diagnostika i lecheniye SPKYa [PCOS: a new view of the problem. Multiple symptoms, diff erential diagnosis and treatment of PCOS]. StatusPraesens, pp. 24.

Сhazenbalk G. (2010) Regulation of adiponectin secretion by adipocytes in the polycystic ovary syndrome: role of tumor necrosis factor-α. J. Clin. Endocrinol. Metab,vol. 95, no 2, pp. 935–942. doi: 10.1210/jc.2009-1158.

Mikhaylova S., Zykova T. (2013) Vitamin D. autoimmunnyye zabolevaniya shchitovidnoy zhelezy i narusheniya reproduktivnoy funktsii u zhenshchin [Vitamin D, autoimmune pathology of thyroid gland and reproductive disorders in women]. Siberian Medical Journal, no 7, pp. 13–17.

Teede H.J., Misso M.L., Costello M.F., Dokras A., Laven J., Moran L., Piltonen T., Norman R.J.; International PCOS Network (2018) Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril., 110 (3), pp. 364–379.

Teede H.J., Misso M.L., Costello M.F., Dokras A., Laven J., Moran L., Piltonen T., Norman R.J.; International PCOS Network (2018) Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril., 110 (3), pp. 364–379.

Hickey M., Doherty D., Atkinson H., Sloboda D., Franks S., Norman R., Hart R. (2011) Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis. Hum Reprod,vol. 26, no 6, pp. 1469–1477. doi: 10.1093/humrep/der102.

Article Statistics

Copyright License

Download Citations

How to Cite

Jamolbek A. Djuraev, Abdurasul J. Botirov, Azizkhon Z. Shaumarov, Sabina Sodikova, Sabrina Kuddusova, Dilafruz Turabaeva, Mukhammadalieva Nurjakhon, & Ambarjon Nurmetova. (2023). POLYCYSTIC OVARY SYNDROME: A MODERN VIEW ON THE PROBLEM. International Journal of Medical Sciences And Clinical Research, 3(02), 83–87. https://doi.org/10.37547/ijmscr/Volume03Issue02-16