Currently, early diagnostics of maternal and paternal Rh status, careful anamnesis, use of Dopplerometry, minimization of invasive diagnostic and therapeutic procedures, and avoidance of immunization development in non-sensitized pregnant women are part of the management of pregnant women with Rh immunization. Recently, more than 260 alleles of the RHD gene have been identified in the Rhesus system. 114 pregnant women with Rh negative blood were examined in the Tashkent Interdistrict Perinatal Center #9 for the period from 2021 to 2024. All the examined pregnant women were divided into 3 groups. Blood sampling was done at the first visit of the pregnant woman to the family health clinic, blood sampling of the newborn was done in the delivery room, from the umbilical artery of the placenta. The frequency of occurrence of Rh-phenotypes in the studied patients was studied. The results showed that among Rh(D)-positive newborns, the most common phenotype was DCcee - (31.6%), followed in descending order by the phenotypes DCCee - (21.4%), DCcEe - (18.6%) and DccEe - (15.9%). Thus, according to the phenotype of the mother with Rh-negative blood type in the presence of a difference from the phenotype of the fetus may depend on the development of hemolytic disease of both the fetus and the newborn. HDFN is developed with the maternal phenotype "ccee" and the fetal phenotype "CCee" in 47.9% of cases, with the maternal phenotype "ccEe" and the fetal phenotype "CCee" in 50.0% of cases, with the maternal phenotype "Ccee" and the fetal phenotype "CCee" in 50.0% of cases, and with the fetal phenotype "Ccee" in 100% of cases.

Rh immunization, Rh group phenotypes, hemolytic disease of the newborn, prevention of Rh immunization of the fetus

Бабаджанова Гулжахон Саттаровна, Саттарова Комола Абдулносировна, Асадова Мухаббат Икромовна ГЕМОЛИТИЧЕСКАЯ БОЛЕЗНЬ НОВОРОЖДЕННОГО, ОБУСЛОВЛЕННАЯ МАТЕРИНСКИМИ АНТИТЕЛАМИ АНТИ -rh"(E) // Биология и интегративная медицина. 2018. №9. URL: https://cyberleninka.ru/article/n/gemoliticheskaya-bolezn-novorozhdennogo-obuslovlennaya-materinskimi-antitelami-anti-rh-e (дата обращения: 20.12.2025).

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