Infertility of endocrine origin is one of the most common pathologies among women of reproductive age and leads to a decrease in the birth rate in society. The aim of the study was a retrospective analysis of the frequency and clinical features of endocrine infertility among women of reproductive age. A retrospective analysis of the incidence of endocrine infertility in 200 women of reproductive age was conducted. Retrospective analysis showed that the main endocrine pathologies, such as hyperprolactinemia, hypothyroidism, and ovulatory dysfunction of the ovaries, accounted for 77% of all cases of infertility. Infertility and a decrease in ovarian reserve (AMG 0.8 ± 0.3 ng/ml; p<0.001), especially in late reproductive age, manifested as a central pathogenetic factor.

Infertility, pituitary dysfunction, hyperprolactinemia

Edinoff AN, Silverblatt NS, Vervaeke HE, Horton CC, Girma E, Kaye AD, Kaye A, Kaye JS, Garcia AJ, Neuchat EE, Eubanks TN, Varrassi G, Viswanath O, Urits I. Hyperprolactinemia, Clinical Considerations, and Infertility in Women on Antipsychotic Medications. Psychopharmacol Bull. 2021 Mar 16;51(2):131-148.

Fang Q, Sang L, Du S, Wang R, Wu H, Yang L, Yu J. Vitamin D, Homocysteine, and Thyroid Dysfunction as Risk Factors for Missed Abortion: A Retrospective Risk Factor Analysis. Int J Womens Health. 2025 May 31;17:1587-1596.

Gierach M, Bruska-Sikorska M, Rojek M, Junik R. Hyperprolactinemia and insulin resistance. Endokrynol Pol. 2022;73(6):959-967.

Jiang NX, Zhao WJ, Shen HR, Du DF, Li XL. Hyperinsulinemia impairs decidualization via AKT-NR4A1 signaling: new insight into polycystic ovary syndrome (PCOS)-related infertility. J Ovarian Res. 2024 Feb 3;17(1):31.

Krysiak R, Szkróbka W, Okopień B. The Impact of Ethinyl Estradiol on Metformin Action on Prolactin Levels in Women with Hyperprolactinemia. Exp Clin Endocrinol Diabetes. 2021 Jan;129(1):22-28.

Kumar M, Yan Y, Jiang L, Sze CH, Kodithuwakku SP, Yeung WSB, Lee KF. Microbiome-Maternal Tract Interactions in Women with Recurrent Implantation Failure. Microorganisms. 2025 Apr 7;13(4):844.

Liu X, Zhang C, Huang J, Liu H, Li B, Zhang F, Xu C. Biomarkers identification in follicular fluid in relation to live birth in in vitro fertilization of women with polycystic ovary syndrome in different subtypes by using UPLC-MS method. Clin Chim Acta. 2024 Apr 15;557:117860.

Ou S, Liao M, Cui L, et al. Associations between microbial presence in follicular fluid with IVF outcomes: a systematic review and meta-analysis. J Assist Reprod Genet. 2023;40(11):2501–11.

Pan M, Qi Q, Li C, Wang J, Pan X, Zhou J, Sun H, Li L, Wang L. Effect and mechanism of Hashimoto thyroiditis on female infertility: A clinical trial, bioinformatics analysis, and experiments-based study. Biosci Trends. 2024 Sep 16;18(4):356-369.

Shan J, Ding J, Li DJ, Wang XQ. The double-edged role of IL-18 in reproductive endocrine and reproductive immune related disorders. Int Immunopharmacol. 2025 Feb 6;147:113859.

Szukiewicz D. Current Insights in Prolactin Signaling and Ovulatory Function. Int J Mol Sci. 2024 Feb 6;25(4):1976.

Tabassum F, Jyoti C, Sinha HH, Dhar K, Akhtar MS. Impact of polycystic ovary syndrome on quality of life of women in correlation to age, basal metabolic index, education and marriage. PLoS One. 2021 Mar 10;16(3):e0247486.

Tian M, Zeng S, Cai S, et al. 25(OH)VitD and human endocrine and functional fertility parameters in women undergoing IVF/ICSI. Front Endocrinol (Lausanne). 2022;13:986848.

Varaldo E, Cuboni D, Prencipe N, et al. Are prolactin levels efficient in predicting a pituitary lesion in patients with hyperprolactinemia? Endocrine. 2024 May;84(2):670-676.

Wang Y, Lu W, Chen ZH, et al. Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates. Adv Mater. 2025 Feb;37(7):e2414129.

Wu YX, Lin YS, Li SC, Yao X, Cheng M, Zhu L, Liu HY. microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor. Reprod Biol Endocrinol. 2021 Nov 23;19(1):170.

Zhu J, Jin J, Qi Q, Zhou Q, Zhou J, Wang L. Drug substitution and adjuvant therapy in patients with genetics related infertility: A review. Drug Discov Ther. 2023 May 15;17(2):73-86.