Increasing the combination of hypertension with osteoarthritis is a public health problem worldwide. Hypertension is associated with osteoarthritis and a high risk of adverse clinical outcomes. In our study, in patients receiving meloxikam, blood pressure increased significantly after treatment, and the proportion of "non-dipper" or extreme categories (over-dipper, night peaker) in 24-hour blood pressure monitoring was higher than in the control group. According to our research results, in the main group, the proportion of over dipper increased from 10% to 3.3% after treatment, dipper type from 46.67% to 60%, non-dipper type from 33.3% to 16.7%, and night peaker type from 10% to 20% (P<0.05). In the control group, these indicators decreased from 13.33% to 10%, from 43.33% to 46.67%, from 30% to 33.33%, and from 13.33% to 10% respectively (P>0.05). These results indicate that meloxicam can relatively worsen blood pressure in patients with hypertension and lead to the formation of latent hypertension.

Hypertension, osteoarthritis, cardiovascular diseases, meloxicam

Constantino de Campos G, Mundi R, Whittington C, Toutounji MJ, Ngai W, Sheehan B. Osteoarthritis, mobility-related comorbidities and mortality: an overview of meta-analyses. Ther Adv Musculoskelet Dis. 2020;12:1759720X20981219. https://doi.org/10.1177/1759720X20981219

Pereira D, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthritis Cartilage. 2011;19(11):1270-85. https://doi.org/10.1016/j.joca.2011.08.009

Palmer KT, Goodson N. Ageing, musculoskeletal health and work. Best Pract Res Clin Rheumatol. 2015;29(3): 391-404. https://doi.org/10.1016/j.berh.2015.03.004

Aronson D, Rayfield EJ. How hyperglycemia promotes atherosclerosis: molecular mechanisms. Cardiovasc Diabetol. 2002;1:1. https://doi.org/10.1186/1475-2840-1-1

Veronese N, Cereda E, Maggi S, Luchini C, Solmi M, Smith T, et al. Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis. Semin Arthritis Rheum. 2016;46(2):160-167. https://doi.org/10.1016/j.semarthrit.2016.04.002.

Roubille C, Coste J, Sellam J, Rat AC, Guillemin F, Roux CH. Association of Baseline Cardiovascular Diseases with 5-Year Knee and Hip Osteoarthritis Progression in Non-Obese Patients: Data from the KHOALA Cohort. J Clin Med. 2021;10(15):3353. https://doi.org/10.3390/jcm10153353.

Safiri S, Kolahi AA, Cross M, Carson-Chahhoud K, Almasi-Hashiani A, Kaufman J, et al. Global, regional, and national burden of other musculoskeletal disorders 1990-2017: results from the Global Burden of Disease Study 2017. Rheumatology (Oxford). 2021;60(2):855-865. https://doi.org/10.1093/rheumatology/keaa315

Sebbag E, Felten R, Sagez F, Sibilia J, Devilliers H, Arnaud L. The world-wide burden of musculoskeletal diseases: a systematic analysis of the World Health Organization Burden of Diseases Database. Ann Rheum Dis. 2019;78(6):844-848. https://doi.org/10.1136/annrheumdis-2019-215142

Omorou AY, Achit H, Wieczorek M, Pouchot J, Fautrel B, Rat AC, Guillemin F. Impact of comorbidities and functional impairment on 5-year loss of health utility in patients with lower-limb osteoarthritis in the KHOALA cohort. Qual Life Res. 2019;28(11):3047-3054. https://doi.org/10.1007/s11136-019-02243-4

Bastick AN, Runhaar J, Belo JN, Bierma-Zeinstra SM. Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies. Arthritis Res Ther. 2015;17(1):152. https://doi.org/10.1186/s13075-015-0670-x

Hall AJ, Stubbs B, Mamas MA, Myint PK, Smith TO. Association between osteoarthritis and cardiovascular disease: Systematic review and meta-analysis. Eur J Prev Cardiol. 2016;23(9):938-46. https://doi.org/10.1177/2047487315610663.

Calders P, Van Ginckel A. Presence of comorbidities and prognosis of clinical symptoms in knee and/or hip osteoarthritis: A systematic review and meta-analysis. Semin Arthritis Rheum. 2018;47(6):805-813. https://doi.org/10.1016/j.semarthrit.2017.10.016.

Hawker GA, Croxford R, Bierman AS, Harvey PJ, Ravi B, Stanaitis I, et al. All-cause mortality and serious cardiovascular events in people with hip and knee osteoarthritis: a population based cohort study. PLoS One. 2014;9(3):e91286. https://doi.org/10.1371/journal.pone.0091286

Mathieu S, Couderc M, Tournadre A, Soubrier M. Cardiovascular profile in osteoarthritis: a meta-analysis of cardiovascular events and risk factors. Joint Bone Spine. 2019;86(6):679-684. https://doi.org/10.1016/j.jbspin.2019.06.013

Courties A, Berenbaum F, Sellam J. The Phenotypic Approachto Osteoarthritis: A Look at Metabolic Syndrome-Associated Osteoarthritis. Joint Bone Spine. 2019;86(6):725-730. https://doi.org/10.1016/j.jbspin.2018.12.005