The menopausal period is a physiological transition period in a woman's life, which occupies the period of time between the reproductive phase and old age.During this period, against the background of age-related changes in the entire body, nevertheless, the involution processes dominate the reproductive system and are characterized by a gradual decrease and shutdown of ovarian function.In the menopausal period, changes such as vasomotor, emotional-vegetative or metabolic disorders occur. It should also be noted in the period from adulthood to old age, against the background of age-related changes, the manifestations of an estrogen deficiency condition, due to an age-related decrease and then the cessation of ovarian function, dominate as indicated above. With the extinction of ovarian function from the body, the calcium content in the blood decreases sharply, which often causes fractures in women at this age. It must be said that the perimenopasal period of life is a kind of risk factor for bone diseases.  We assessed the state of the bone system of 68 perimenopausal women aged 55 to 65 years. The condition of the women was assessed according to the following criteria: complaints, general examination, anamnesis, as well as hormonal status, blood levels of Ca and vit.D,. The transdermal gel Estrogel was used as a hormonal drug. Estrogel should be applied once daily in a thin layer to the skin of the lower abdomen, shoulder,or forearm.

Menopause, osteoporosis, diagnosis, calcium content, estrogel

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