Preterm newborns present unique challenges in the development of intestinal microbiota, which significantly influences their immune system, metabolic processes, neurological development, and overall adaptive capacity. This article, based on a systematic literature review, examines the role of intestinal microbiota in preterm infants, highlights the clinical consequences of dysbiosis, explores its impact on neuropsychological development via the gut-brain axis, and discusses modern therapeutic and diagnostic strategies. Findings indicate that breastfeeding and probiotic supplementation help stabilize the microbiota, while advanced molecular diagnostic technologies enable early detection of complications and the implementation of personalized therapeutic approaches (Tamburini et al., 2016; Warner & Hamvas, 2018).

Preterm infants, intestinal microbiota, neonatal adaptation, probiotics

Underwood, M. A. (2019). Probiotics and the prevention of necrotizing enterocolitis. Journal of Pediatric Surgery, 54(3), 405–412.

Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., ... & Ventura, M. (2017). The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiology and Molecular Biology Reviews, 81(4), e00036-17.

Neu, J., & Pammi, M. (2018). Pathogenesis of NEC: Impact of an altered intestinal microbiome. Seminars in Perinatology, 41(1), 29–35.

Ho, T. T. B., Groer, M. W., & Kane, B. (2019). Human milk, lactation, and neonatal microbiome. Seminars in Perinatology, 43(7), 151–158.

Sherman, M. P. (2010). New concepts of microbial translocation in the neonatal intestine: mechanisms and prevention. Clinical Perinatology, 37(1), 565–579.

Warner, B. B., & Hamvas, A. (2018). Gut microbiome and preterm infant health. Seminars in Fetal and Neonatal Medicine, 23(6), 404–409.

Patel, R. M., & Denning, P. W. (2015). Intestinal microbiota and its relationship with necrotizing enterocolitis. Pediatric Research, 78(3), 232–238.

Tamburini, S., Shen, N., Wu, H. C., & Clemente, J. C. (2016). The microbiome in early life: implications for health outcomes. Nature Medicine, 22(7), 713–722.

Walker, W. A. (2017). The importance of appropriate initial bacterial colonization of the intestine in newborns: a commentary. Pediatric Research, 82(3), 387–395.

Arrieta, M. C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014). The intestinal microbiome in early life: health and disease. Frontiers in Immunology, 5, 427.