Articles | Open Access | https://doi.org/10.37547/ijmscr/Volume05Issue05-20

The Role of Lipid Peroxidation and Activity of The Blood Antioxidant System in The Development of Postpartum Endometritis and Their Prognostic Significance

Iroda Kamilova , Obstetrics and gynecology in family medicine department Tashkent medical academy, Tashkent, Uzbekistan, Uzbekistan
Aziz Umarov , Obstetrics and gynecology in family medicine department, Tashkent medical academy, Tashkent, Uzbekistan

Abstract

Postpartum endometritis is one of the most common infectious complications in the postpartum period. According to various authors, the incidence of endometritis after natural childbirth is 1-3%, while after cesarean section, the rate is 27% [3,5,12,13,18]. The frequency of cesarean sections in Uzbekistan has been steadily increasing from 9.58% in 1999 to 16.10% in 2019. In perinatal centers of Uzbekistan in 2017-2020. Thus, the determining of predictor factors which play huge role in the development of postpartum endometritis is relevant. In this article are given the results of scientific work which was done with 89 women who were after delivery in order to predict postpartum endometritis.

Keywords

Endometritis, postpartum period, lipid peroxidation, antioxidant system

References

A. Amany, E.Rania, D. Lawahez, “Effect of Pre-Elective Cesarean Section Vaginal Cleansing using Povidone-Iodine versus Chlorhexidine on the Incidence of Post-Cesarean Infections,” Egyptian Journal of Health Care, vol. 13, pp.864-874, 2022.

A. Angelo., M. Peracchini, A. Agostini, “The Impact of Oxidative Stress on Pregnancy. The Neglected Role of Alcohol Misuse,” Clin Ter., vol. 175, pp. 47-56, 2024.

D. Axelsson, J. Brynhildsen, M. Blomberg, “Postpartum infection in relation to maternal characteristics, obstetric interventions and complications,” J Perinat Med., vol. 25, pp. 271-278, 2018.

D. Axelsson, J. Brynhildsen, M. Blomberg, “Postpartum infection in relation to maternal characteristics, obstetric interventions and complications,” J. Perinatal Med, vol 46(3) pp. 271–8, 2018;

J. Joó, E. Sulyok, J. Bódis, L. Kornya, “Disrupted Balance of the Oxidant-Antioxidant System in the Pathophysiology of Female Reproduction: Oxidative Stress and Adverse Pregnancy Outcomes,” Curr Issues Mol Biol, vol 4, pp. 8091-8111, 2023.

T. Karakaya, D. Keskin, “Hematological and Inflammatory Parameters to Predict the Develop Surgical Infection After Cesarean Section,” Mid Blac Sea Journal of Health Sci, vol 10, pp. 71-80, 2024.

M. Knight, V. Chiocchia, C. Partlett, “Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial,” Lancet, vol 393, pp. 2395–2403, 2019.

A. Mackeen, R. Packard, E. Ota, L. Speer, “Antibiotic regimens for postpartum endometritis,” Cochrane Database of Systematic Reviews, 2015.

M. Chika, I., Ndiamaka, “Antioxidants Properties of Natural and Synthetic Chemical Compounds: Therapeutic Effects on Biological System,” Acta Scientific Pharmaceutical Sciences, vol 3, pp. 28-42, 2015.

N. Merino de Paz, M. García-González, F. Gómez-Bernal, “Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus,” Antioxidants (Basel), vol 12, pp. 1535, 2023.

N. Banashree, H. Roy, “Antioxidants in Female Reproductive Biology’. Antioxidants - Benefits, Sources, Mechanisms of Action,” IntechOpen, Septepmber 2021.

J. Ngonzi, L. Bebell, Y. Fajardo, A. Boatin, M. Siedner, I. Bassett, Y. Jacquemyn, J. Van Geertruyden, J. Kabakyenga, “Incidence of postpartum infection, outcomes and associated risk factors at Mbarara regional referral hospital in Uganda,” BMC Pregnancy Childbirth, vol 18, pp. 270, 2018.

L Say, D. Chou, A. Gemmill, Ö. Moller, “Global causes of maternal death: a WHO systematic analysis,” The Lancet Global Health, vol 2, pp. 323–333, 2018.

L. Plante, L. Pacheco, J. Louis, “Sepsis during pregnancy and the puerperium,” Am. J. Obstet. Gynecol, vol 220, pp.2–10, 2019.

C. Rouse, L. Eckert, F. Muñoz, J. Stringer, S. Kochhar, “Postpartum endometritis and infection following incomplete or complete abortion: Case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data,” Vaccine, vol 37, pp. 7585–7595, 2019.

A.Silvestrini, E.Meucci, B. Ricerca, A.Mancini, “Total Antioxidant Capacity: Biochemical Aspects and Clinical Significance,” Int. J. Mol. Sci., vol 24, pp. 10978, 2019.

A. Wong., A. Rosh, F. Talavera, “ Postpartum infections clinical presentation”, 2018.

S. Woodd, A. Montoya, M. Pi, L. Barreix, C. Calvert, A. Rehman, “Incidence of maternal peripartum infection: A systematic review and meta-analysis,” PLoS Med, vol 16, 2019.

C. Zhang, Y.Yang, R Chen, Y.Wei, Y.Feng, “Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients,” Am. J. Transl. Res., vol 11, pp. 269–279, 2019.

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Iroda Kamilova, & Aziz Umarov. (2025). The Role of Lipid Peroxidation and Activity of The Blood Antioxidant System in The Development of Postpartum Endometritis and Their Prognostic Significance. International Journal of Medical Sciences And Clinical Research, 5(05), 96–104. https://doi.org/10.37547/ijmscr/Volume05Issue05-20