Affective-respiratory paroxysm (ARP) is an episodic loss of consciousness that occurs in children, and its mechanism is not fully understood. The aim of this study was to evaluate the state of oxidative stress and antioxidant defense system in children with ARP. The results show that the ARP group had higher levels of malondialdehyde (MDA) and reactive oxygen species (ROS), while the activity of antioxidant enzymes (SOD and GPx) was decreased. This indicates that the imbalance between oxidative stress and the antioxidant defense system may play an important role in the development of ARP. Therefore, it is important to evaluate the effectiveness of antioxidant therapy in future studies.
Associations between oxidative stress and antioxidant protection system in affective-respiratory paroxysm
DOI:
Keywords:
Affective-respiratory paroxysm
oxidative stress
antioxidant defense system
Abstract
References
Ghezzi, P. (2020). Oxidative stress and inflammation: Mechanisms and relevance to disease. Free Radical Biology and Medicine, 157, 4-6. https://doi.org/10.1016/j.freeradbiomed.2020.05.010
Halliwell, B., & Gutteridge, J. M. C. (2019). Free radicals in biology and medicine (5th ed.). Oxford University Press.
Kane, M., Roberts, L., & Thompson, J. (2021). Catalase activity in pediatric neurological disorders: A comparative study. Journal of Pediatric Biochemistry, 14(3), 112-119. https://doi.org/10.1002/jpbi.2021.003
Tain, Y. L., Hsu, C. N., & Chan, J. Y. H. (2022). Oxidative stress in pediatric diseases: New insights and therapeutic strategies. International Journal of Molecular Sciences, 23(5), 2451. https://doi.org/10.3390/ijms23052451