
ASSESSMENT OF TOXIC COMPLICATIONS OF CHRONOCHEMOTHERAPY IN THE TREATMENT OF MALIGNANT TUMOR DISEASES
Karimov M.A. , Namangan State University, Faculty Of Medicine, Uzbekistan, Namangan, Uzbekistan Makhmudova R.Y. , Kosonsoy Abu Ali Ibn Sino Public Health Technical University, Namangan, Uzbekistan Abduraimova R.A. , Kosonsoy Abu Ali Ibn Sino Public Health Technical University, Namangan, Uzbekistan O'rinboev M.R. , Kosonsoy Abu Ali Ibn Sino Public Health Technical University, Namangan, Uzbekistan Beknazarov A.T. , Kosonsoy Abu Ali Ibn Sino Public Health Technical University, Namangan, Uzbekistan Nurkabilov O.T. , Kosonsoy Abu Ali Ibn Sino Public Health Technical University, Namangan, UzbekistanAbstract
the Andijan regional oncology dispensary analyzed the 120 patients on the "D" account for the side effects observed after chemotherapy and chronochemotherapy treatments. In 80-90% of patients receiving chemotherapy, different manifestations of side effects are observed. The observation of these toxic complications is explained by the effect of the cytostatic drug on typical cells.
Keywords
Chemotherapy, chronochemotherapy, toxic complications
References
Arushanyan E.B., Baturin V.A. Fundamentals of chronopharmacology, Stavropol, 1989. 67 p.
Bekhtereva I. Ya. Neurophysiological aspects of mental activity. - L .: Medicine, 1974. - 151 p.
V. GRINEVICH. ilmiy journal “Science and Life”, 2005 yil No. 1 dream.
Valiev O.M., Ismailov Sh.I., 1990. 109 p.
Vasilyeva G. S. Chronobiology and chronotherapy of malignant neoplasms (experimental clinical studies): Abstract of the thesis. dis. Dr. Biol. Sciences. - Almaty, 1994 - 78 p.
Dobrokhotov V.N. et al., Atypical cell morphology. 1964. 111 p.
Efimov M. L. Biological rhythms in norm and pathology. - Alma-Ata, 1981. - 152 p.
M. L. Efimov, G. S. Vasil’eva, V. R. Kovalenko, et al., Vopr. oncology. - 1989. - T. 35, N 9. - S. 1068-1071.
Zaslavskaya R. M. Chronodiagnosis and chronotherapy of diseases of the cardiovascular system.— M.: Medicine, 1991.— 320 p.
Komarov F. I., Zakharov A. V., Lisovskiy V. A. Daily rhythm of physiological functions in a healthy person. - L .: Medicine, 1966. - 200 p.
F. I. Komarov and S. I. Rapoport, Klin. medicine. - 1993. - N 5. - S. 4-9.
Komarova F.I., Rapoporta S.I. Chronobiology and chronomedicine / Ed. – 2nd ed. - M.: Triada-X, 2000. - 488 p.
Moiseeva N. I., Sysuev V. M. Temporal environment and biological rhythms.- L .: Nauka, 1981.- 127 p.
Oransky I. E., Tsarfis P. G. Biorhythmology and chronotherapy (chronobiology and chronobalneophysiotherapy).— M.: Vyssh. shk, 1989.— 159 p.
Romanov Yu.A., 2000;
Tabolin V.A. et al., 1969
Ulashchik V.S., biological rhythms and chronotherapy, journal. Medical news. 1996 No. 2.
Chissov V. I., Davydov M. I. Oncology national leadership. - Moscow, Goetar media, 2014. - 483 p.
Beryozkin M.V., chronopharmacology. 1977, 259 p.
Hrushesky W. // Science. - 1985. - V. 228, N 4695. - P. 73-75.
Oransky I. et al., Science. - 1995. - V. 202, N 1269. - P. 43-46.