This article explores the phenomenon of human trafficking in Uzbekistan, examining the socio-economic and political factors contributing to its prevalence. It provides a comprehensive analysis of the stages in the formation of the national system designed to combat human trafficking, detailing the development of legal frameworks, institutional mechanisms, and preventive measures. The study highlights the challenges faced in implementing effective anti-trafficking strategies and the progress achieved over the years. By assessing the efficacy of current policies and practices, the article aims to offer recommendations for strengthening Uzbekistan's approach to combating human trafficking and improving the protection of victims.