This article discusses the science of rhyme (qofiya), an integral part of classical Eastern poetics. It examines the historical development of rhyme, the types and positions of rhyme letters, and their occurrence within roots and affixes, using Alisher Navoi and the Ottoman Turkish poet Lamii Chalabi’s Farhod and Shirin as primary examples. The study employs formal and comparative-typological methods to analyze the rhyme groups—such as mujarrad, murdaf, muqayyad, and mu’assas—found in the verses of these epics, offering explanations for their usage. As a result, the paper reveals how rhyme letters function in the works of Alisher Navoi and Lamii Chalabi, shedding light on the formation and structural features of rhyme within languages belonging to the same linguistic family.