Across the human lifespan endocrine rhythms undergo predictable transitions that reorganise brain circuitry, autonomic balance and behaviour. Pubertal gonadarche, reproductive senescence in women and the gradual androgen decline in men constitute three major inflection points. Yet their psychophysiological sequelae—spanning affect regulation, cognitive trajectory and stress responsivity—remain incompletely mapped in Central Asian populations. The present convergent-methods study combines (i) a systematic appraisal of articles published from 2023-2025 and (ii) original cross-sectional data from 312 healthy Uzbek participants aged 10-75 years. Serum estradiol, progesterone, testosterone and cortisol were assayed; concurrent electrodermal activity, heart-rate variability and event-related potentials indexed autonomic and cortical responsiveness. Multivariate analyses revealed stage-specific patterns: heightened cortisol reactivity and amygdala-potentiated startle during early puberty, oestrogen-linked preservation of verbal memory in peri-menopausal women, and diminished vagal tone paralleling late-life testosterone decline. Extreme menopausal ages (< 40; > 55 years) predicted lower baseline cognition independent of education. Findings integrate global evidence with regional data, underscoring that age-related hormonal shifts are key modulators of psychophysiological health and should guide preventive interventions.  

Puberty, menopause, andropause

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