Articles
| Open Access |
https://doi.org/10.37547/ajbspi/Volume05Issue11-04
Early Predictors Of Graft Function In Pediatric Living-Related Kidney Transplantation
Abstract
Objective. To identify simple and clinically accessible early predictors of graft function in children after living-related kidney transplantation. Materials and Methods. A retrospective analysis of 50 pediatric kidney transplantations performed from 2018 to 2025 was conducted. All transplants were obtained from first-degree related donors. The following parameters were analyzed: preoperative creatinine, hemoglobin, sodium, potassium levels, daily urine output in the first 24 hours after transplantation, and creatinine dynamics on postoperative days 1, 3, and 7. The prognostic significance of early diuresis and creatinine reduction was evaluated. Results. All patients demonstrated pronounced early diuresis (5–8 L/day) during the first postoperative day. A consistent decrease in serum creatinine was observed: 495 ± 30 μmol/L on day 1, 215 ± 18 μmol/L on day 3, and 97 ± 9 μmol/L on day 7. Patients with more intensive early diuresis showed faster normalization of creatinine levels. No cases of delayed graft function or primary non-function were observed. Conclusion. Daily urine output in the first 24 hours and the rate of serum creatinine reduction within the first 7 days are reliable and easily accessible early predictors of adequate graft function in children after living-related kidney transplantation.
Keywords
Pediatric kidney transplantation, early graft function, predictors, diuresis, creatinine
References
Baigent C. et al. Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference //Kidney international. – 2017. – Т. 92. – №. 2. – С. 297-305.
Eknoyan G. et al. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease //Kidney int. – 2013. – Т. 3. – №. 1. – С. 5-14.
Shapiro R. et al. Pediatric Solid Organ Transplantation. – 2023.
Filler G. Challenges in pediatric transplantation: The impact of chronic kidney disease and cardiovascular risk factors on long‐term outcomes and recommended management strategies //Pediatric transplantation. – 2011. – Т. 15. – №. 1. – С. 25-31.
Good R. A. The Minnesota scene: a crucial portal of entry to modern cellular immunology //The Immunologic Revolution. – CRC Press, 2024. – С. 105-168.
Ismailov SI, Khaydarov AE, Mamasiddikov SM, Narziev MZh, Khamraev GM, Nosirov RN, Sobirov DM, and Mardonov ZhN. Analysis of risk factors and outcomes of acute kidney injury in young children after cardiac surgery. J Life Sci Biomed, 2023; 13(4): 59-65. DOI: https://dx.doi.org/10.54203/jlsb.2023.9
Lentine KL, Smith JM, Lyden GR, Miller JM, Dolan TG, Bradbrook K, Larkin L, Temple K, Handarova DK, Weiss S, Israni AK, Snyder JJ. OPTN/SRTR 2022 Annual Data Report: Kidney. Am J Transplant. 2024 Feb;24(2S1):S19-S118. doi: 10.1016/j.ajt.2024.01.012. PMID: 38431360.
Shapiro R. et al. (ed.). Pediatric Solid Organ Transplantation: A Practical Handbook. – Springer Nature, 2023.
Wlodkowski T, Haeberle S, Schaefer F. Das Europäische Referenznetzwerk für seltene Nierenerkrankungen (ERKNet) [The European Rare Kidney Disease Reference Network]. Inn Med (Heidelb). 2024 Dec;65(12):1283-1292. German. doi: 10.1007/s00108-024-01810-3. Epub 2024 Nov 13. PMID: 39538006
Khaydarov AE, Mardonov JN, Sobirov DM, et al. Morphological picture of acute kidney injury in young children after cardiac surgery. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 65-70. DOI: 10.20969/VSKM.2024.17(6).65-70.
Ismailov SI, Khaydarov AE, Mamasiddikov SM, Narziev MZh, Khamraev GM, Nosirov RN, Sobirov DM, and Mardonov ZhN. Analysis of risk factors and outcomes of acute kidney injury in young children after cardiac surgery. J Life Sci Biomed, 2023; 13(4): 59-65. DOI: https://dx.doi.org/10.54203/jlsb.2023.9
Ismailov SI, Bakhritdinov FS, Khaibullina ZR, Suyumov AS, Akhmedov AR, Mardonov JN. Improving approaches to donor selection for living-related kidney transplantation: monograph. Tashkent: Zamin Nashr; 2025. 164 p.
Hariharan S., Johnson C.P., Bresnahan B.A., et al. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med. 2000;342:605–612.
Meier-Kriesche H.U., Ojo A.O., Hanson J.A., et al. Increased impact of acute rejection on chronic allograft failure in recent era. Transplantation. 2000;70(7):1098–1100.
Nankivell B.J., Alexander S.I. Rejection of the kidney allograft. N Engl J Med. 2010;363:1451–1462.
Article Statistics
Copyright License
Copyright (c) 2025 Makhmudov Kodirjon Oltinboevich, Mardonov Jamshid Normurotovich, Urinov Jasur Bahodirovich, Nabijonov Bahodirbek Sodiqjon ugli

This work is licensed under a Creative Commons Attribution 4.0 International License.