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American Journal Of Biomedical Science & Pharmaceutical Innovation

Peer Reviewed | Open Access | E-ISSN: 2771-2753
Published Article

Janus Kinase Inhibitors In The Treatment Of Axial Spondyloarthritis

Janus Kinase Inhibitors In The Treatment Of Axial Spondyloarthritis

Authors

  • Mukhammadieva S.M.
    Tashkent state medical university, Uzbekistan
  • Rakhimzoda F.E.
    Tashkent state medical university, Uzbekistan

DOI:

https://doi.org/10.37547/ajbspi/Volume05Issue10-14

Keywords:

Axial spondyloarthritis janus kinases cytokine sulfasalazine

Abstract

The aim of the study was to study the clinical and laboratory efficacy and safety of tofacitinib in patients with axial spondyloarthritis (axSpA).

Material and methods. The study included 40 axSpA patients aged 18 to 55 years who were treated in the rheumatology department of the multidisciplinary clinic of the Tashkent state medical university. Based on the purpose of the study, the patients were divided into two groups: group 1- 20 patients received tofacitinib 5 mg 1 tab x 2 times, group 2 – 20 patient received sulfasalazine 500 mg 1 tab x 3 times after meals for 12 weeks.

Conclusion. After 12 weeks treatment taking tofacitinib 10 mg/day in 2/3 patients and sulfasalazine 1,5 g/day in ¼ patients with axSpA , the activity of sacroiliitis decreased. The frequency of side effects between tofacitinib and sulfasalazine did not differ significantly.

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