Articles
| Open Access |
https://doi.org/10.37547/ajbspi/Volume05Issue10-13
Modulatory Effects Of Polyphenol R-1 On Calcium Transport And Synaptosomal Function In Experimental Hypothyroidism
Abstract
The present study investigated the corrective effect of the polyphenol R-1 on neuronal calcium transport and synaptosomal function in rats with experimental hypothyroidism. Hypothyroidism was induced in adult male rats by oral administration of mercazolil (2.5 mg/100 g) for 21 days. Model validation was confirmed through behavioral (Open Field Test), biochemical, and hormonal analyses. Hypothyroid rats exhibited decreased triiodothyronine (T3) and thyroxine (T4) levels, elevated thyrotropin (TSH), impaired biochemical parameters in brain homogenates, and a marked reduction in intracellular calcium concentration in brain synaptosomes. Treatment with polyphenol R-1 (50 mg/kg, orally, 14 days) significantly corrected behavioral hypoactivity, normalized serum hormone profiles, restored biochemical markers, and increased synaptosomal calcium levels toward control values. Mechanistically, R-1 modulated the activity of NMDA receptors and voltage-gated calcium channels, stabilizing calcium homeostasis and synaptic transmission. These findings demonstrate that polyphenol R-1 exerts neuroprotective and calcium-regulatory effects in hypothyroid-induced neuronal dysfunction, suggesting its potential as a therapeutic agent for thyroid-related neuropathologies.
Keywords
Hypothyroidism, Polyphenol R-1, NMDA receptor, Calcium homeostasis
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