Under the influence of external factors, changes in the physical properties and chemical composition of medicinal plant extracts can occur, which in turn affects their stability and therapeutic efficacy. The shelf life of a dosage form is the primary quality indicator, determining its stability over the intended shelf life. It is known that the preservation of quality parameters depends on many factors, such as excipients, manufacturing techniques, and the type of packaging material.

Tablet stability is greatly influenced by the physical state of the substance, storage temperature, ambient atmosphere, light, packaging, preparation method, selection of excipients, and other factors. It should be noted that the intensity of these effects often manifests itself over time and to a greater or lesser degree. Given the above, studying the shelf life and storage conditions of developed dosage forms is the final stage of scientific research.

Extract, extraction, various factors

Государственная фармакопея Российской Федерации.-12-е изд.-Часть 2.-М.:Науч.центр экспертизы средств мед.применения, 2010.-810 с.

Государственная фармакопея Российской Федерации / МЗ РФ. –XIII изд.-Т.1.-Москва, 2015.-1470 с.

Государственная фармакопея Российской Федерации / МЗ РФ. -XIII часть 1, ОФС1.009.15 «Сроки годности лекарственных средств», с. 192.

Q1A(R2) “Stability testing of new drugs ubstances and products” CPMP/ICH/2736/99 (утверждено 02/2003; действует с 08/ 2003) Изучение стабильности новых АФИ и препаратов.

Yunusova X.M., Sunnatov Sh.X., Jaloliddinova M. Sh., Anvarova F.J. On The Development Of The Technology For "Prostad" Capsules Based On Natural Origin Substances // Central Asian Journal Of Medical And Natural Sciences 2024, 6(1). -P. 161-168.

Yunusova Kh.M., Sunnatov Sh.Kh. Selection of the optimal composition and technology of the recommended capsules "PROSTAD" // International Journal of Medical Sciences And Clinical Research 2025. Vol.05 Issue03 - P. 21-30. DOI 10.37547/ijmscr/Volume05Issue03-05

Руководство по экспертизе лекарственных средств. Том III. – М.: Полиграф-Плюс, 2014– 344, Изучение стабильности и установление сроков годности лекарственных средств, с. 224.

ТУ 64-7-678-90 Тубы и бушоны для медицинских мазей. Технические условия, с. 25.

Временная инструкция по проведению работ с целью определения сроков годности лекарственных средств на основе метода «ускоренного старения» при повышенной температуре. – И-42-2-82.-М., 1983.-С.2-8.

Yunusova Kh.M., Sunnatov Sh.Kh. Determination of qualitative and quantitative indicators of dry extract of cypress naturalis plant // Eurasian Journal Of Medical And Natural Sciences, 2025. Volume 5 Issue 4. – P. 46- 55. ISSN 2181-287X, IF = 7. doi.org/10.5281/zenodo.15167835

Yunusova Kh. M., Sunnatov Sh. Kh. Study of Biopharmaceutical Properties of Recommended Capsules "Prostad" by in Vitro and in Vivo Method // International Journal of Scientific Trends- (IJST) ISSN: 2980-4299 2025. Volume 4, Issue 4, P. 1- 9.

Yunusova Kh.M., Ilkhamova N.B., Sunnatov Sh.Kh. Selecting the Optimal Method and Technology for Obtaining Dry Extract of Epilobium Angustifolium // International Journal of Medical Sciences And Clinical Research Vol.05 Issue05 2025.- P. 11-17. DOI 10.37547/ijmscr/Volume05Issue05-03