Personalized Approach to The Diagnosis of Neuropathic Pain in Metastatic Breast Cancer: Development of A Multicomponent Questionnaire | American Journal Of Biomedical Science & Pharmaceutical Innovation

Authors

Rakhimov Nodir Makhammatkulovich

DSc, Professor, Department of Oncology, Samarkand State Medical University, Samarkand 140100, Uzbekistan
Rakhmonov Kamol Aminzhonovich

Independent researcher, Department of Oncology, Samarkand State Medical University, Samarkand 140100, Uzbekistan
Shakhanova Shakhnоza Shavkatovna

PhD, Associate Professor, Department of Oncology, Samarkand State Medical University, Samarkand 140100, Uzbekistan

DOI:

https://doi.org/10.37547/ajbspi/Volume05Issue06-09

Keywords:

Neuropathic pain breast cancer questionnaire

Abstract

Objective: To validate the specialized questionnaire "NEURO-RMZh" for the differential diagnosis of neuropathic pain in patients with metastatic breast cancer and to compare its psychometric properties with existing validated instruments.

Materials and Methods: A single-center prospective validation study was conducted, enrolling 111 patients with metastatic breast cancer. A comprehensive methodological approach was employed, including assessment of internal consistency, test-retest reliability, construct and criterion validity. Statistical methods included factor analysis, correlation analysis, ROC analysis, and multiple logistic regression. The DN4, BPI, SF-36, and Visual Analogue Scale (VAS) questionnaires were used as comparators.

Results: The "NEURO-RMZh" questionnaire demonstrated high internal consistency (Cronbach’s α = 0.89) and test-retest reliability (ICC = 0.94). Its four-factor structure explains 73.6% of the total variance. The diagnostic performance of the questionnaire exceeds that of existing tools: sensitivity 89.7%, specificity 82.4%, area under the ROC curve 0.92. Likelihood ratios (LR+ = 5.10, LR- = 0.13) indicate the clinical significance of the test. Strong correlations were observed with SF-36 quality of life domains (r from -0.44 to -0.74).

Conclusion: The "NEURO-RMZh" questionnaire is a valid, reliable, and highly informative tool for the differential diagnosis of neuropathic pain in patients with metastatic breast cancer. Its implementation may contribute to the optimization of diagnostics and personalization of therapeutic strategies in palliative oncology.

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