This study delves into the theoretical frameworks necessary to understand aging mechanisms involving soft and hard electrophiles. Aging, a complex biological process, is influenced by various chemical interactions, including those between electrophiles and cellular components. Soft electrophiles, characterized by their high polarizability, and hard electrophiles, known for their low polarizability, interact differently with biomolecules, leading to distinct pathways of cellular damage and repair. By examining these interactions through a theoretical lens, the research aims to elucidate the roles of electrophilic stress in aging, propose models for these mechanisms, and highlight potential targets for anti-aging interventions.

Aging mechanisms, soft electrophiles, theoretical frameworks

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