
MORPHOGENETIC CHARACTERISTICS OF KERATODERMA IN METABOLIC DISORDERS
Abstract
Studying the morphological and genetic different types of keratoses is key for correct diagnosis and choice of treatment. The association between metabolic disorders and skin diseases highlights the need for an integrated approach to the management of patients with chronic diseases, including diabetes mellitus. Further research is needed to better understand the pathogenesis and develop effective treatments.
Keywords
Morphology, skin, keratoderma
References
Кожные и венерические болезни. Справочник. Под ред. О.Л.Иванова. М: Медицина 2007; 117—118.
Родионов А. Н., Заславский Д. В., Сыдиков А. А. Клиническая дерматология. – 2019.
Болезнь Кирле (кератоз фолликулярный и парафолликулярный, проникающий): клинический случай В.В. КАРПОВ1КЛИНИЧЕСКАЯ ДЕРМАТОЛОГИЯ И ВЕНЕРОЛОГИЯ 5, 2011стр.25-28).
Huang J. et al. An epidemiological study on skin tumors of the elderly in a community in Shanghai, China //Scientific Reports. – 2023. – Т. 13. – №. 1. – С. 4441.
Alapatt G. F., Sukumar D., Bhat M. R. A clinicopathological and dermoscopic correlation of seborrheic keratosis //Indian Journal of Dermatology. – 2016. – Т. 61. – №. 6. – С. 622-627.
Kim H.S., Park E.J., Kwon I.H., Kim K.H., Kim K.J. Clinical and histopathologic study of benign lichenoid keratosis on the face. Am. J. Dermatopathol. 2013; 35(7): 738–41.].
Mohamed M., Amri M., Njim L., Jribi M., Zakhama A., Zili J. Pigmented keratosis on the face. Ann. Dermatol. Venereol. 2013; 140(5): 390-2.
Bruecks A.K., Kalia S., Trotter M.J. Overexpression of p27 KIP1 in seborrheic keratosis. J. Cutan. Med. Surg. 2007; 11(5): 174–8.
Hafner C., van Oers J.M., Hartmann A., Landthaler M., Stoehr R., Blaszyk H., et al. High frequency of FGFR3 mutations in ad¬enoid seborrheic keratoses. J. Invest. Dermatol. 2006; 126(11): 2404–7.,
Ruas M., Gregory .F, Jones R., Poolman R., Starborg M., Rowe J., et al. CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. Mol. Cell Biol. 2007; 27(12): 4273–82.
Seargent J.M., Loadman P.M., Martin S.W., Naylor B., Bibby M.C., Gill J.H. Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma. Urology. 2005; 65(4): 815-20.
Morgan D. Cell Cycle: Principals of Control. London: New Sci¬ence Press Ltd.; 2007: 145–6., Mitrea D.M., Yoon M.K., Ou L., Kriwacki R.W. Disorder-func¬tion relationships for the cell cycle regulatory proteins p21 and p27. Biol. Chem. 2012; 393(4): 259–74.
Mitrea D.M., Yoon M.K., Ou L., Kriwacki R.W. Disorder-func¬tion relationships for the cell cycle regulatory proteins p21 and p27. Biol. Chem. 2012; 393(4): 259–74.
Pellegata N.S., Quintanilla-Martinez L., Siggelkow H., Sam¬son E., Bink K., Hofler H., et al. Germ-line mutations in p27 Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc. Natl. Acad. Sci. U.S.A. 2006; 103(42): 15558–63.
Александрова А.К.1, Суколин Г.И.2, Смольянникова В.А.ОСОБЕННОСТИ ЭКСПРЕССИИ БЕЛКА p27 ПРИ РАЗНЫХ ФОРМАХ СЕБОРЕЙНОГО КЕРАТОЗА Российский журнал кожных и венерических болезней 2016,19 (5) стр.283-286.
Karadag A. S., Parish L. C. The status of the seborrheic keratosis //Clinics in Dermatology. – 2018. – Т. 36. – №. 2. – С. 275-277.
Jackson J. M. et al. Current understanding of seborrheic keratosis: prevalence, etiology, clinical presentation, diagnosis, and management //Journal of drugs in dermatology: JDD. – 2015. – Т. 14. – №. 10. – С. 1119-1125.
Sanders M. G. H. et al. Prevalence and determinants of seborrhoeic dermatitis in a middle‐aged and elderly population: the Rotterdam Study //British Journal of Dermatology. – 2018. – Т. 178. – №. 1. – С. 148-153.
Squillace L. et al. Unusual dermoscopic patterns of seborrheic keratosis //Dermatology. – 2016. – Т. 232. – №. 2. – С. 198-202.
Wollina U. Recent advances in managing and understanding seborrheic keratosis //F1000Research. – 2019. – Т. 8.
Del Rosso J. Q. A closer look at seborrheic keratoses: patient perspectives, clinical relevance, medical necessity, and implications for management //The Journal of clinical and aesthetic dermatology. – 2017. – Т. 10. – №. 3. – С. 16.
Bagazgoitia L, Cuevas J, Juarranz A. Expression of p53 and p16 in actinic keratosis, Bowenoid actinic keratosis and Bowen's disease. J Eur Acad Dermatol Venereol. 2010;24(2):228–30.
Broers J. L. V., Ramaekers F. C. S. The role of the nuclear lamina in cancer and apoptosis //Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes. – 2014. – С. 27-48.
Talghini S, Halimi M, Baybordi H. Expression of p 27, Ki 67, p 53 in squamous cell carcinoma, actinic keratosis and Bowen disease. Pakistan Journal of Biological Sciences. 2009;12(12):929–33. doi: 10.3923/pjbs.2009.929.933.
Ahlgrimm-Siess V. et al. Seborrheic keratosis: reflectance confocal microscopy features and correlation with dermoscopy //Journal of the American Academy of Dermatology. – 2013. – Т. 69. – №. 1. – С. 120-126.
Papadavid E, Pignatelli M, Zakynthinos S, Krausz T, Chu AC. Abnormal immunoreactivity of the E-cadherin/catenin (alpha-, beta-, and gamma-) complex in premalignant and malignant non-melanocytic skin tumours. J Pathol.2002;196(2):154–62.
Fuller LC, Allen MH, Montesu M, Barker JN, Macdonald DM. Expression of E-cadherin in human epidermal non-melanoma cutaneous tumours. Br J Dermatol. 1996;134(1):28–32.).
Хлебникова А.Н., Гуревич Л.Е., Селезнева Е.В., Обыденова К.В., Седова Т.Г.,Кунцевич Ж.С. Особенности пролиферации и межклеточной адгезии в предраковых и злокачественных эпителиальных опухолях кожи. Альманах клинической медицины. 2016 Январь; 44 (1): 58–63.
Aljada A. et al. Altered Lamin A/C splice variant expression as a possible diagnostic marker in breast cancer //Cellular Oncology. – 2016. – Т. 39. – С. 161-174.
Dubik N., Mai S. Lamin A/C: function in normal and tumor cells //Cancers. – 2020. – Т. 12. – №. 12. – С. 3688.
Blomberg M., Jeppesen E.M., Skovby F., Benfeldt E. "FGFR3 Mutations and the Skin: Report of a Patient with a FGFR3 Gene Mutation, Acanthosis Nigricans, Hypochondroplasia and Hyperinsulinemia and Review of the Literature." Dermatology 220.4 (2010):297–300. DOI: 10.1159/000297575.
Kim Y. The impact of altered lamin B1 levels on nuclear lamina structure and function in aging and human diseases //Current Opinion in Cell Biology. – 2023. – Т. 85. – С. 102257.
Saraiya A., Al-Shoha A., Brodell R.T. "Hyperinsulinemia Associated with Acanthosis Nigricans, Finger Pebbles, Acrochordons, and the Sign of Leser-Trélat." Endocr. Pract. 19.3 (2013): 522–555. DOI: 10.4158/EP12192.RA.
Squillace L, Cappello M, Longo C, Moscarella E, Alfano R, Argenziano G. Unusual dermoscopic patterns of seborrheic keratosis. Dermatology. 2016;232(2): 198–202. doi:10.1159/000442439. 19.
Roh NK, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Clinical and histopathological investigation of seborrheic keratosis. Ann Dermatol. 2016;28(2):152–8. doi: 10.5021/ad.2016.28.2.152.
Tardío J.C., Bancalari E., Moreno A., Martín-Fragueiro L.M. "Genital Seborrheic Keratoses Are Human Papillomavirus-related Lesions. A Linear Array Genotyping Test Study." APMIS. 120.6 (2012): 477–483. DOI: 10.1111/j.1600-0463.2011.02853.x.,
Jackson JM, Alexis A, Berman B, Berson DS,Taylor S, Weiss JS. Current understanding of seborrheic keratosis: prevalence, etiology, clinical presentation, diagnosis, and management.J Drugs Dermatol. 2015;14(10): 1119–25. 18.
Squillace L, Cappello M, Longo C, Moscarella E, Alfano R, Argenziano G. Unusual dermoscopic patterns of seborrheic keratosis. Dermatology. 2016;232(2): 198–202. doi: 10.1159/000442439. 19.
Roh NK, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Clinicaland histopathological investigation of seborrheic keratosis. Ann Dermatol. 2016;28(2): 152–8. doi: 10.5021/ad.2016.28.2.152.
Martin B.C., Warram J.H., Krolewski A.S., Bergman R.N., Soeldner J.S., Kahn C.R. "Role of Glucose and Insulin Resistance in Development of Type 2 Diabetes Mellitus: Results of a 25-year Follow-up Study." Lancet 340 (1992): 925–929.,
Юсупова Л. А. и др. Патогенетические механизмы, диагностика и клиническая картина себорейного кератоза //Лечащий врач. – 2018. – №. 10. – С. 73.
Saraiya A., Al-Shoha A., Brodell R.T. "Hyperinsulinemia Associated with Acanthosis Nigricans, Finger Pebbles, Acrochordons, and the Sign of Leser-Trélat." Endocr. Pract. 19.3 (2013): 522–555.
Elder D.E., Elenitsas R., Johnson B.L. Jr, Murphy G.F., Xu X. Lever's Histopathology of the Skin. Philadelphia: Lippincott-Raven, 2009. 795–798
Пашинян А. Г., Джаваева Д. Г., Молчанова О. В. Себорейный дерматит в практике врача-косметолога. Клинические проявления. Диагностика. Лечение //Метаморфозы. – 2018. – №. 24. – С. 12-16..
Alapatt GF, Sukumar D, Bhat MR. A clinicopathological and dermoscopic correlation of seborrheic keratosis. Indian J Dermatol. 2016;61(6):622–7.
Saraiya A., Al-Shoha A., Brodell R.T. "Hyperinsulinemia Associated with Acanthosis Nigricans, Finger Pebbles, Acrochordons, and the Sign of Leser-Trélat." Endocr. Pract. 19.3 (2013): 522–555. DOI: 10.4158/EP12192.RA.
Choi HJ, Lee JH. Multiple human papilloma virus 16 infection presenting as various skin lesions. J Craniofac Surg. 2016;27(4):e379–81.
Wu YH, Hsiao PF, Chen CK. Seborrheic keratosis with bowenoid transformation: the immunohistochemical features and its association with human papillomavirus infection. Am J Dermatopathol. 2015;37(6): 462–8.
Писклакова Т.П., Костенко Е.И., Телешева Л.Ф. Себорейный кератоз: клинические особенности и ассоциация с вирусом папилломы человека рода β Альманах клинической медицины. 2017 Март-апрель; 45 (2): 118–126.
Rayess H., Wang M. B., Srivatsan E. S. Cellular senescence and tumor suppressor gene p16 // Int. j. cancer – 2012. – V. 130 (8). – P. 171–174.,
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