Over the past 15 years, the incidence of cancer of the oral cavity, pharynx, and larynx has increased by 15-17%, and almost 90% of patients are working people (30-60 years old). There were 32 patients (15 men and 17 women) aged 35 to 60 years with oral precancerous diseases examined at the department of Therapeutic Dentistry of Tashkent State Dental Institute. An IHC study in patients diagnosed with flat leukoplakia did not reveal neoplastic transformation of epithelial cells; the main changes in the epithelium were characterized by hyperplasia with cell proliferation.
IMMUNOHISTOCHEMICAL MARKERS IN DIAGNOSTICS OF ORAL PRECANCEROUS DISEASES
DOI:
Keywords:
Oral precancerous diseases
diagnostics
immunohistochemistry
Abstract
References
A retrospective 20-year analysis of proliferative verrucous leukoplakia and its progression to malignancy and association with high-risk human papillomavirus /J. D. Upadhyaya, S. G. Fitzpatrick, M. N. Islam [et al.] // Head Neck Pathol. – 2018. –Dec., Vol. 12(4). – P. 500–510.
A study on the intrapapillary capillary loop detected by narrow band imaging system in early oral squamous cell carcinoma / R. Sekine, T. Yakushiji, Y. Tanaka [et al.] //J. Oral Maxillofac. Surg. Med. Pathol. – 2015. – Vol. 27. – P. 624–630.
Accuracy of autofluorescence in diagnosing oral squamous cell carcinoma and oral potentially malignant disorders: A comparative study with aero‐digestive lesions / X. Luo, H. Xu, M. He [et al.]. – Text: electronic // Scientific Reports. – 2016. –Vol. 6. – 29943. – URL: https://www.researchgate.net/ publication/305369840 (date of access: 09.10.2021).
Advances of salivary proteomics in oral squamous cell carcinoma (OSCC) detection: an update / R. Sannam Khan, Z. Khurshid, S. Akhbar [et al.]. – Text: electronic // Proteomes. – 2016. – Dec. 15, Vol. 4(4). – 41. – URL: https://pubmed.ncbi.nlm.nih.gov/28248250/ (date of access: 09.10.2021).
Alsarraf, A. Liquid-based oral brush cytology in the diagnosis of oral leukoplakia using a modified Bethesda Cytology system / A. Alsarraf, O. Kujan C. S. Farah // Journal of Oral Pathology & Medicine. – 2018. – Oct., Vol. 47(9). –P. 887–894.
Alsarraf, A. H. The utility of oral brush cytology in the early detection of oral cancer and oral potentially malignant disorders: A systematic review /A H. Alsarraf, O. Kujan, C. S. Farah // Journal of Oral Pathology & Medicine. – 2017. – Vol. 47(2). – P. 104–116.
Berman, J. Candida Albicans: A molecular revolution built on lessons from budding yeast / J. Berman, P. Sudbery // Nature Reviews Genetics. – 2002. – Vol. 3(12). – P. 918–930.
Bombeccari, G. P. Oral Candida colonization and oral lichen planus /G. P. Bombeccari, A. B. Giannì, F. Spadari // Oral Disease. – 2017. – Vol. 23(7). –P. 1009–1010.