FORMULATION, DEVELOPMENT, AND EVALUATION OF A FAST-DISSOLVING DRUG: A NOVEL APPROACH

Abstract

Fast-dissolving drugs have become increasingly popular due to their convenience and ease of administration, particularly for patients who have difficulty swallowing or require rapid onset of action. However, the development and formulation of such drugs can be challenging as they need to maintain their stability and efficacy despite the accelerated dissolution rate. In this study, we aimed to formulate and develop a fast-dissolving drug using a novel approach and evaluate its properties and performance. We used a combination of direct compression and freeze-drying techniques to formulate and develop the drug, with the excipients mannitol, crospovidone, and microcrystalline cellulose. Our optimized formulation achieved a disintegration time of less than 30 seconds and a dissolution rate of over 90% within 2 minutes. The taste of the drug was rated as acceptable by the majority of the panelists. Stability testing showed that the drug remained effective and stable over a period of 12 months, with no significant degradation or loss of potency. Our study demonstrates the successful development and formulation of a fast-dissolving drug using a combination of direct compression and freeze-drying techniques, with promising results in terms of disintegration time, dissolution rate, taste, and stability.