Vaccination is essential in preventing infectious diseases, particularly in pediatric populations. However, optimizing vaccine efficacy while minimizing post-vaccination complications in children remains a significant challenge due to the developmental state of their immune systems. This article reviews current strategies for enhancing vaccine effectiveness, including the use of adjuvants, improved vaccine formulations, and personalized vaccination schedules. Additionally, it explores methods to reduce post-vaccination complications, such as pre-vaccination screening, prophylactic treatments, and minimizing antigen load. These approaches aim to provide better protection for children while ensuring safety and reducing adverse effects. The findings highlight the need for continued research into vaccine optimization tailored to pediatric needs, particularly in the era of advanced vaccine technologies.

This article analyses the present condition of technological applications based on artificial intelligence (AI) and their influence on the healthcare sector. This work conducted a comprehensive literature research and examined certain real-world instances of AI implementations in the healthcare sector. Undoubtedly, the fast progress of artificial intelligence (AI) and associated technologies will enable healthcare providers to provide fresh value for their patients and enhance the effectiveness of their internal operations. However, successful deployment of AI will always pose distinct problems and the adoption of specific approaches to revolutionize the whole care service and operations in order to fully utilize the advantages of future technology. The analysis is derived on an examination of several academic sources, encompassing research from ScienceDirect, MDPI, Elsevier, and the Journal of Consortium. These sources address studies and data published from recent years till 2024.

Primaquine is an effective antimalarial drug known for its ability to target hepatic stages of malaria parasites. However, its use is often limited by oxidative stress and subsequent damage to erythrocytes, which can lead to hemolysis and other adverse effects. Pravastatin, a widely used statin with known antioxidant properties, has potential therapeutic applications beyond cholesterol management. This study aims to investigate the protective and antioxidant effects of pravastatin on erythrocytes loaded with primaquine, evaluating its efficacy in mitigating oxidative damage and preserving erythrocyte integrity.

Erythrocytes were incubated with primaquine to induce oxidative stress, and then treated with various concentrations of pravastatin. Parameters such as lipid peroxidation, glutathione levels, and erythrocyte membrane integrity were assessed using spectrophotometric and biochemical assays. The extent of oxidative damage was compared between treated and untreated erythrocytes. Pravastatin demonstrated a significant reduction in oxidative stress markers, including decreased lipid peroxidation and increased glutathione levels, in erythrocytes loaded with primaquine. Furthermore, pravastatin treatment effectively preserved erythrocyte membrane integrity, as evidenced by improved cell viability and reduced hemolysis. Pravastatin exhibits notable antioxidant activity and protective effects on erythrocytes exposed to primaquine-induced oxidative stress. These findings suggest that pravastatin could serve as a beneficial adjunctive treatment in managing oxidative damage associated with primaquine therapy, potentially improving patient outcomes in malaria treatment.

Bioactive groups were identified and methods for their identification and determination in the herbal preparation Sedavit, tablets, were developed. Methods were developed for high-performance liquid chromatography (HPLC) for the identification of polyphenolic compounds and the quantitative determination of pyridoxine and nicotinamide; gas chromatography (GC) for the determination of isovaleric acid, spectrophotometry (SP) for the quantitative determination of flavonoids.

In patients with purulent-necrotic processes in diabetes mellitus, the condition of the IL-1B, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, INF system based on the dynamics of cytokine levels was studied. Complex surgical treatment of the drug Reomannisol corrects the balance of cytokines, allowing them to have an antioxidant effect on the cytokine system.

Military service is a very specific type of activity, during which the human body can be exposed to a whole range of unfavorable factors of various etiologies. The most difficult period in military service is the initial adaptation period, when the physiological and psychological restructuring of the soldier's body occurs, his adaptation to life and everyday life, to the requirements of the military environment. Adaptation of military personnel to military activities affects the success of this activity, as well as the preservation of the health of military personnel. The study of the features of the process of adaptation to military service seems important for organizing high-quality training of personnel and achieving the ability of military personnel to withstand significant physical and neuropsychic stress. All this also applies to students of military educational institutions. In this case, motivation will be understood as a time-limited psychophysiological process that controls the behavior of an individual, setting its direction, organization, activity and stability; the ability of a person to actively satisfy his needs, while further acting in the interests of the state and society. One of the important areas of this work, which has great practical significance, is the study, assessment and forecasting of the adaptive capabilities of the cadets' body. Most often, psychological diagnostic methods are used to determine the level of adaptation, but recently instrumental research methods, in particular, heart rate variability analysis, have become increasingly widespread.

The article shows the results of 12 pregnant women with a complication of idiopathic thrombocytopenic purpura in the form of hemorrhagic syndrome. Their clinic, diagnosis, conservative and surgical treatment. Traditional and inhalation injection of glucocorticoid hormones, as well as intravenous injection of immunoglobulin in 75% of patients had positive effect and remission was obtained on days 3-4. If the conservative treatment was ineffective, surgeries were performed splenectomy (SE), and uterine bleeding stopped on 2-3 days and platelets increased to 210 thousand. During pregnancy, patients with idiopathic thrombocytopenic purpura (ITP), complicated by hemorrhagic syndrome, conservative and surgical treatment in 100% of cases performed a positive effect.

Autism spectrum disorders are a neurological pathology with a number of characteristic features, which are expressed in social isolation, lack of initiative in dating, difficulties in understanding social signals such as facial expressions and gestures, which makes it difficult to interact with others. And children, being susceptible to ASD, quite often suffer from loneliness and are not infrequently subjected to great stress due to their inability to perceive the world normally. Difficulties with ASD arise from childhood, when a child begins to join society.

The absence of lipids in Total Parenteral Nutrition (TPN) solutions can significantly impact the growth and proliferation of microorganisms, which is crucial for ensuring the safety and efficacy of TPN preparations. This study investigates microbial growth patterns in lipid-free TPN solutions by examining both the rate and types of microorganisms that proliferate in these conditions. Using a series of controlled laboratory experiments, we analyzed the growth of common pathogens and non-pathogenic microorganisms in lipid-free TPN solutions over time. Our results indicate a marked difference in microbial growth dynamics compared to lipid-containing TPN solutions, with specific microorganisms exhibiting enhanced growth in the absence of lipids. These findings underscore the need for rigorous monitoring and stringent sterilization practices for lipid-free TPN solutions to prevent potential contamination and ensure patient safety. The study highlights the critical role that lipids play in the microbial stability of TPN solutions and suggests that further research is necessary to develop effective strategies for mitigating microbial risks in lipid-free formulations.

This work provides a general overview of load in athlete training. Excessive physical activity requires a certain amount of energy expenditure. The magnitude of force is dependent on the size of the load, which after a certain time leads to fatigue and the need for recovery. Training involves energy expenditure and fatigue, while also promoting recovery processes. These processes not only lead to full recovery but also ensure supercompensation, which fully restores work capacity under submaximal and maximal loads.