Root canal treatment is a critical procedure in endodontics, aiming to preserve the integrity of the dentin while eliminating infection within the root canal system. Irrigation solutions play a crucial role in this process, yet their impact on dentin integrity remains a subject of study and debate. This paper conducts a comprehensive analysis of the effects of irrigation solutions on root canal dentin. Through an examination of various irrigation solutions, including their chemical composition and interactions with dentin, this analysis aims to elucidate their influence on dentin structure, properties, and bond strength. Moreover, the potential implications for clinical outcomes and long-term success of root canal treatment are explored. By synthesizing existing research findings, this paper provides valuable insights into optimizing irrigation protocols to preserve dentin integrity and enhance the efficacy of root canal therapy Root canal treatment, dentin integrity, irrigation solutions, endodontics, chemical composition, bond strength.

Endometriosis is still a widespread and at the same time not fully studied disease, being one of the urgent problems of modern medicine. The problem becomes even more important due to functional and structural changes in the reproductive system of women with endometriosis, in whom the frequency of infertility reaches 55-75%. To date, none of the proposed strategies for the treatment of endometriosis has led to its complete cure. ideas about the etiopathogenesis and tactics of management of patients with endometriosis-associated infertility according to the data of domestic and foreign literature.

Metabolic syndrome is a group of conditions that occur together and increase the risk of heart disease, stroke and type 2 diabetes. These conditions include high blood pressure, high blood sugar, excess fat around the waist and abnormal cholesterol levels. The prevalence of metabolic syndrome is steadily increasing worldwide, with an estimated 25% of adults worldwide affected. Pharmacotherapy plays a critical role in the treatment of metabolic syndrome to control individual components of the syndrome and reduce the risk of cardiovascular disease and other complications. Treatment for metabolic syndrome usually involves a combination of lifestyle changes such as diet and exercise and medications to control blood pressure, blood sugar, and cholesterol levels.

Thin endometrium, a condition characterized by an abnormally thin uterine lining, can pose significant challenges to a woman's reproductive health, particularly in achieving pregnancy. This article delves into the intricacies of thin endometrium, encompassing its prevalence, associated problems, underlying causes, risk factors, diagnostic methods, and treatment options.

Peritonitis is a severe complication of inflammatory and destructive diseases of the abdominal organs, with severe local and general symptoms, with the development of multiple organ failure. With widespread peritonitis, the mortality rate is 20-30%, and with the most severe forms this figure increases to 40-50%. Because of this, the topic of peritonitis is still on the agenda. The article presents a retrospective analysis of data from 1830 patients who were treated in the surgical department of the 4th Clinical Hospital named after. I. Irgashev in 2023. This scientific analysis focuses on the extent and effectiveness of surgical interventions selected based on the clinical course, duration and extent of peritonitis. At the same time, the article also studied the reaction of the morphological structures of the peritoneum in accordance with the duration and spread of the inflammatory process during peritonitis.

The number of caesarean sections around the world is increasing every year. This is influenced by the rapid development of modern medical science, the improvement of surgical techniques, the emergence of new suture materials and broad-spectrum antibiotics, pain relief, and the change in society's attitude to childbirth. According to the World Health Organization (WHO), caesarean section (CS) is the most widely used operative method of childbirth today. Determining the role of CS practice in the search for ways to reduce perinatal and maternal morbidity and mortality is essential. In some cases, this method of delivery is the only way to reduce maternal mortality: premature separation of the normally located placenta and the appearance of signs of its partial separation, severe hypertensive conditions, including a severe degree of preeclampsia and eclampsia, somatic complications that lead to complications in the mother's natural delivery pathologies.

Thus, the tactics of taking women with a scar on the uterus through natural childbirth, with adequate prenatal preparation, the development of criteria for assessing the adjustment of the surgical scar, the lack of special criteria for predicting the probability of natural childbirth in pregnant women who underwent cesarean section, the special urgency of finding a solution to these issues defines. Therefore, it is necessary to study the condition of women with uterine scars, to improve the tactics of pregnancy and childbirth management, as well as the methods of preventing and predicting complications.

This article provides important information on the adoption and results of artificial intelligence-based surgical decisions in the treatment of acute cholecystitis.

The problem of cervical cancer prevention (cervical cancer) is interdisciplinary since it can be solved only through the joint efforts of gynecologists, oncologists, virologists, and immunologists. The role of human papillomaviruses in the development of oncological processes is considered. The main emphasis is placed on the pathogenetic mechanisms of cervical cancer, where the etiotropic role of viruses is beyond doubt.  the role of cellular protein p53 and hormonal factors (estrogens) in the carcinogenesis of HPV-infected cervical epithelial cells, immunological control of HPV-induced cervical cancer.

These articles present a study focused on the identification and characterization of fungal species associated with spoilt fruits in India. Fungal contamination of fruits can lead to significant economic losses and pose risks to human health. This research aimed to isolate and identify fungal species from various types of spoilt fruits using morphological and molecular techniques. The study provides insights into the diversity of fungal pathogens affecting fruits in India and their potential implications for food safety and agriculture.

Diagnosis of cervical intraepithelial neoplasia in women with a history of exocervix ablation is difficult due to the displacement of the junction of the squamous and prismatic epithelium into the cervical canal. Diagnostic significance in these cases belongs to the data of cytological examination of cells obtained with the help of a cyto-brush from the cervical canal. The diagnosis was clarified by coni biopsy. In 20 (17%) of the 70 women followed, CIN and cervical cancer were detected. Patients with ablation exocervixes have a history of developing intracervical neoplasias with the persistence of highly oncogenic types of HPV (human papillomavirus), so they need endocervix cytological control, viral load, and papillomavirus genotype annually as secondary prevention of cervical cancer.

Gynecology is a branch of medicine that focuses on the health of the female reproductive system. Over the years, advancements in technology and research have led to significant progress in the field of gynecology. This article aims to provide an overview of the current trends in gynecology, highlighting the latest developments and innovations that are shaping the future of women's healthcare

Inflammatory gynecological diseases (IGDs) are a group of conditions that cause inflammation of the female reproductive organs. Various infections, including bacteria, viruses, fungi, and protozoa can cause them. IGDs can lead to serious complications, such as infertility, ectopic pregnancy, and cancer.

The number of caesarean sections around the world is increasing every year. This is influenced by the rapid development of modern medical science, the improvement of surgical techniques, the emergence of new suture materials and broad-spectrum antibiotics, pain relief, and the change in society's attitude to childbirth. According to the World Health Organization (WHO), caesarean section (CS) is the most widely used operative method of childbirth today. Determining the role of CS practice in the search for ways to reduce perinatal and maternal morbidity and mortality is essential. In some cases, this method of delivery is the only way to reduce maternal mortality: premature separation of the normally located placenta and the appearance of signs of its partial separation, severe hypertensive conditions, including a severe degree of preeclampsia and eclampsia, somatic complications that lead to complications in the mother's natural delivery pathologies.

According to WHO, diseases caused by the herpes simplex virus occupy the second place after influenza [1,4,5]. It has been established that up to 80% of cases of temporary disability are associated with inflammatory eye diseases, 50-60 of them% they receive inpatient treatment. According to various authors, a significant place among the causes of blindness or visual impairment (10-30% of cases) belongs to keratitis and keratouveitis. Most often, this corneal disease is caused by the herpes simplex virus, which are noted in 20-57% of cases among in the adult population and in 70-80% of cases - among children [3|. But at the same time, some authors report that herpetic primary infection is usually found in young children, but in a cold form and does not require treatment. In this regard, we decided to share our experience in the treatment of herpetic keratitis in children.

Approaches to organ-preserving treatment of uterine fibroids began to develop in parallel with the creation of radical methods of treating this disease, but this direction has always lagged somewhat behind and had few supporters. Recently, organ-preserving treatment of uterine fibroids has become one of the priority areas. In general, this is a completely natural process, due to both the development of modern treatment technologies and the growing need of women to solve reproductive problems. What is the reason for this? On the one hand, there is a persistent tendency to get pregnant at a late reproductive age, on the other hand, uterine fibroids are increasingly diagnosed in young, nulliparous women. In addition, the development of the media and the Internet is of no small importance, which, in turn, began to pay more attention to health and medical issues, covering new medical technologies.

Effective organ-preserving treatment of uterine fibroids is impossible without a full understanding of this disease. The concept of "uterine fibroids" includes a heterogeneous group of conditions that characterize pathological changes in the uterus. The doctor can call uterine fibroids a single node in the uterus 1 cm in size, which does not have any clinical manifestation, and multiple uterine fibroids, corresponding to 25 weeks of pregnancy, manifested by bleeding and compression of adjacent organs. Therefore, the approach to the treatment of this disease largely depends on the correct clinical classification. The currently existing classifications (histological and localization) are unacceptable in practical gynecology and in fact do not carry any tactical information. The currently widely used indications for hysterectomy in practice make it possible to observe patients up to the turn of 12 weeks, i.e., they allow passivity in relation to patients with smaller fibroids. Thus, a classification is needed that combines such characteristics as: size, number of nodes, localization, and reproductive plans of the patient, that is, a classification is needed that allows the doctor to predict treatment tactics immediately.