The work is devoted to a review of the options for the use of collagen and materials based on collagen in medicine and the pharmaceutical industry. Tissue engineering is a medical science dealing with the reproduction of biological tissues and organs. This area of medicine opens avenues for the creation of organs and tissues using biomaterials and nanostructures to sustain their development, maintenance, and function repair in a living organism. Among the many types of cells that can have a clinical effect, of particular interest are dermal fibroblasts, which are a heterogeneous population of mesenchymal cells and play a key role in the regulation of cell interactions and maintaining skin homeostasis. Currently, there are more than 60 modern cellular or tissue drugs for the treatment of wounds, which makes it difficult to choose an appropriate, safe, and effective adjuvant therapy. Recent years have witnessed a major leap in 3D technology for the reproduction of biological structures. Increasing attention is being paid to the controlled design and production of 2D–3D structures consisting of biological materials and viable cells, the procedure defined as bioproduction or bio-prototyping. Skin substitutes obtained with the bio-prototyping technology possess a wide range of medical applications, primarily to compensate for resident skin deficiency in wound healing.

Collagen, Collost, biomaterial

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Zokhirov, A. (2023). SURGICAL TREATMENT OF TRACHEAL STENOSIS WITH SCARS. Journal of Academic Research and Trends in Educational Sciences, 2(1), 236-241.

Зохиров, А. Р. (2023). СОВРЕМЕННЫЕ ПРИНЦИПЫ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ ОСТРОГО АППЕНДИЦИТА У БЕРЕМЕННЫХ. European Journal of Interdisciplinary Research and Development, 13, 121-126.

Fozilovich, M. S., Yusufjanovich, E. U., & Rafiqovich, Z. A. (2023). IMPROVEMENT OF METHODS OF PROVIDING OUTPATIENT SURGICAL CARE IN PRIMARY HEALTH CARE. British Journal of Global Ecology and Sustainable Development, 14, 50-57.

Fozilovich, M. S., Mamatkulovich, M. B., & Rafiqovich, Z. A. (2023). METHODS OF APPROACHES TO IMPROVING THE QUALITY AND EFFECTIVENESS OF THE PREVENTIVE WORK OF SURGEONS IN CLINICS. Conferencea, 74-78.

Rafiqovich, Z. A. (2023). SURGICAL TREATMENT OF ACUTE APPENDICITIS IN PREGNANCY. British Journal of Global Ecology and Sustainable Development, 14, 32-38.

Ergashev, U., & Zohirov, A. (2023). STUDYING THE EFFICACY OF MODERN SCLEROTHERAPY IN VASCULAR SURGERY. Journal of Academic Research and Trends in Educational Sciences, 2(1), 211-217.

Ergashev, U., & Zohirov, A. (2023). COURSE AND PRINCIPLES OF TREATMENT OF ACUTE APPENDICITIS IN PREGNANCY. Journal of Academic Research and Trends in Educational Sciences, 2(1), 218-225.

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Rafiqovich, Z. A., Sobirjonovich, S. S., Faxriddinovich, F. F., & Ubaydullaxonovich, O. S. (2023). Experimental Treatment of Purulent-Necrotic Lesions of The Lower Extremities with New Generation Drugs. Texas Journal of Medical Science, 18, 30-38.

Rafiqovich, Z. A., Sobirjonovich, S. S., Faxriddinovich, F. F., & Ubaydullaxonovich, O. S. (2023). THE ROLE OF MODERN SCLEROTHERAPY IN VASCULAR SURGERY. American Journal of Interdisciplinary Research and Development, 14, 1-6.

Зохиров, А. Р., & Эрназаров, Х. И. (2022, June). Патоморфологическая картина жизненноважных органов при экспериментальной модели диабетической стопы. In International scientific forum-2022 (pp. p146-153).

Эрназаров, Х., Зохиров, А., Эргашев, У. Ю., & Исраилов, Р. (2022). ПАТОМОРФОЛОГИЧЕСКАЯ КАРТИНА ЖИЗНЕННО ВАЖНЫХ ОРГАНОВ ПРИ ЭКСПЕРИМЕНТАЛЬНОЙ МОДЕЛИ ДИАБЕТИЧЕСКОЙ СТОПЫ.

Yusufjanovich, E. U., Rafiqovich, Z. A., & Tohirovich, G. B. (2023). PRINCIPLES OF STUDYING LIVER MORPHOLOGY IN EXPERIMENTAL DIABETIC FOOT SYNDROME. World Bulletin of Public Health, 19, 63-65.

Abduraimovna, A. F., Komilovna, S. G., Yusufjanovich, E. U., & Rafiqovich, Z. A. (2023, February). EVALUATION OF THE EFFECTIVENESS OF PHYSICAL ACTIVITY IN PELVIC ORGAN PROLAPSE. In E Conference Zone (pp. 42-48).

Атаходжаева, Ф. А., Сохибова, Г. К., Эргашев, У. Ю., & Зохиров, А. Р. (2023, February). ВЛИЯНИЯ ВИТАМИНА Д НА ТАКТИКУ ВЕДЕНИЯ ЖЕНЩИН С МИОМОЙ МАТКОЙ. In E Conference Zone (pp. 35-41).

Yusufjanovich, E. U., Irisbaevich, M. G., Rafiqovich, Z. A., Abduraimovna, A. F., & Komilovna, S. G. (2023, February). IDIOPATHIC THROMBOCYTOPENIC PURPURA IN PREGNANCY. In E Conference Zone (pp. 13-20).

Rafiqovich, Z. A. (2023, February). IMPROVING THE DETECTION OF MORPHOLOGICAL CHANGES IN PURULENT WOUNDS. In E Conference Zone (pp. 51-57).

Zokhirov, A. R. (2022, June). Ernazarov Kh. I. In THE STUDY OF PATHOPHYSIOLOGICAL CHANGES IN PURULENT-NECROTIC PROCESSES OF THE DIABETIC FOOT SYNDROME." International scientific forum-2022 (pp. p597-605).

Zohirov, A. R., Ergashev, U. Y., & Ernazarov, H. I. (2022, June). Qandli diabetda oyoqning yiringlinekrotik shikastlanishlarining patomorfologik jihatlarini kompleks davolashni o'rganish. In International scientific forum-2022 (pp. p132-136).

Ergashev, U. Y., Zokhirov, A. R., & Minavarkhujaev, R. R. (2023). Study and treatment of changes in biochemical processes in complications of diabetes mellitus.

Зохиров, А. Р., Эрназаров, Х. И., & Эргашев, У. Ю. (2022, January). ПАТОМОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ЗАЖИВЛЕНИЯ РАН ПРИ ЭКСПЕРИМЕНТАЛЬНОЙ МОДЕЛИ ДИАБЕТИЧЕСКОЙ СТОПЫ. 64-ОЙ НАУЧНО-ПРАКТИЧЕСКОЙ КОНФЕРЕНЦИИ ОБУЧАЮЩИХСЯ «НАУКА И ЗДОРОВЬЕ» ПОСВЯЩЕННАЯ ДНЮ НАУКИ РЕСПУБЛИКИ КАЗАХСТАН С МЕЖДУНАРОДНЫМ УЧАСТИЕМ.

Эргашев, У. Ю., Зохиров, А. Р., Мустафакулов, Г. И., & Моминов, А. Т. (2023). ОЦЕНКА ПРИМЕНЕНИЯ И ЭФФЕКТИВНОСТИ СОВРЕМЕННЫХ ОПЕРАТИВНЫХ ВМЕШАТЕЛЬСТВ НА ПАТОЛОГИЧЕСКИХ ПРОСТРАНСТВАХ ПЕЧЕНИ. European Journal of Interdisciplinary Research and Development, 12, 17-26.

Эрназаров, Х. И., Эргашев, У. Ю., Зоҳиров, А. Р., & Каримов, Х. Я. (2022). ЭФФЕКТИВНОСТЬ ИСПОЛЬЗОВАНИЕ ПРЕПАРАТА РЕОМАННИСОЛ В ЛЕЧЕНИИ ЭКСПЕРИМЕНТАЛЬНОЙ МОДЕЛИ ДИАБЕТИЧЕСКОЙ СТОПЫ.

Ergashev, U. Y., Zokhirov, A. R., & Minavarkhujaev, R. R. (2022). Determination of changes in the lipid peroxidase index in purulent-necrotic lesions of the lower extremities.

Зохиров, А. Р., & Набиева, А. Ш. (2023). ИЗУЧЕНИЕ ПАТОМОРФОЛОГИЧЕСКИХ ОСОБЕННОСТЕЙ СОВРЕМЕННОГО ЛЕЧЕНИЯ ГНОЙНО-НЕКРОТИЧЕСКИХ ПРОЦЕССОВ ПРИ САХАРНОМ ДИАБЕТЕ. Interpretation and researches, 1(2), 25-36.

Ergashev, U. Y., Zokhirov, A. R., & Minavarkhujaev, R. R. (2023). The study of pathological physiology of indicators of endogenous intoxication in purulent-necrotic lesions of the lower extremities.

Зохиров, А. Р. (2023). ОБОСНОВАНИЕ ПРОЦЕССОВ ЭПИТЕЛИЗАЦИИ И РЕГЕНЕРАЦИИ ПРИ ГНОЙНО-НЕКРОТИЧЕСКИХ ПРОЦЕССАХ НИЖНИХ КОНЕЧНОСТЕЙ ПРИ САХАРНОМ ДИАБЕТЕ. Conferencea, 174-180.

Rafiqovich, Z. A. (2023). OBSERVATION OF BIOCHEMICAL RESULTS IN EXPERIMENTAL DIABETIC FOOT SYNDROME. Conferencea, 181-188.

Rafiqovich, Z. A. (2023). MONITORING OF THE REGENERATION PROCESS IN PURULENT-NECROTIC PROCESSES OF THE LOWER EXTREMITIES. Conferencea, 189-194.

Rafiqovich, Z. A. (2023). STUDY OF THE EFFECT OF LIPID PEROXIDASE ANALYSIS ON THE BODY IN DIABETIC FOOT SYNDROME. Conferencea, 76-82.

Rafiqovich, Z. A. (2023). CONTROL OF INDICATORS OF ENDOTOXICOSIS IN DIABETIC FOOT SYNDROME. Conferencea, 83-90.

Yusufjanovich, E. U., Irisbaevich, M. G., Rafiqovich, Z. A., & Irsaliyevich, E. K. (2023). EVALUATION OF EFFECTIVENESS OF SPLENECTOMY IN CHRONIC LEUKEMIAS. World Bulletin of Public Health, 19, 79-83.

Yusufjanovich, E. U., Rafiqovich, Z. A., Tashkarganovich, M. A., & Tohirovich, G. B. (2023). ASSESMENT THE EFFECTIVENESS OF MINIMALLY INVASIVE SURGICAL METHODS IN ACUTE CHOLECYSTITIS. International Journal of Scientific Trends, 2(2), 14-23.

Yusufjanovich, E. U., & Rafiqovich, Z. A. (2023). The Use of Endovascular Laser Coagulation in the Recurrence of Varicose Veins of the Lower Extremities. International Journal of Scientific Trends, 2(2), 24-31.

Эргашев, У. Ю., & Зохиров, А. Р. (2023). ОЦЕНКА ЭФФЕКТИВНОСТИ МАЛОИНВАЗИВНЫХ ОПЕРАЦИЙ ПРИ МЕХАНИЧЕСКОЙ ЖЕЛТУХЕ И ПРИМЕНЕНИЕ АЛГОРИТМА. European Journal of Interdisciplinary Research and Development, 12, 6-16.

Ergashev, U. Y., Zohirov, A. R., Minavarkhojayev, R. R., & Mominov, A. T. (2023). IMPROVING METHODS FOR DIAGNOSING AND MONITORING ENDOTOXICOSIS IN EXPERIMENTAL DIAETIC FOOT SYNDROME. World Bulletin of Public Health, 19, 84-95.

Ergashev, U. Y., Zokhirov, A. R., & Ernazarov, K. I. (2022). THE STUDY OF PATHOMORPHOLOGICAL DIAGNOSIS OF VITAL ORGANS AFTER MODERN TREATMENT OF DIABETIC FOOT SYNDROME.

Ergashev, U. Y., Zokhirov, A. R., & Ernazarov, K. I. (2022). THE STUDY OF DIAGNOSTICS AND PREVENTION OF PATHOPHYSIOLOGICAL PARAMETERS AFTER MODERN TREATMENT OF PURULENT-NECROTIC PROCESSES IN DIABETIC.

Ergashev, U. Y., Mustafakulov, G. I., Muminov, A. T., Minavarkhujaev, R. R., Yakubov, D. R., Ernazarov Kh, I., & Zohirov, A. R. (2021). The role of minimally invasive technologies in the treatment of liver cavities. Frontiers in Bioscience-Landmark, 8, 82-89.

Ergashev, U. Y., Mustafakulov, G. I., Mominov, A. T., Yakubov, D. R., Zohirov, A. R., & Ernazarov, X. I. (2022). Effective of Simultaneous Surgeries in Chronic Immune Thrombocytopenia. Jundishapur Journal of Microbiology, 15(2), 638-644.

Ergashev, U. Y. (2022). Ernazarov Kh. I., Zohirov AR, Alzabni ID 2022. Complex Treatment of Experimental Model of Diabetic Foot Syndrome. American Journal of Medicine and Medical Sciences, 12(5), 471-480.

Yusufjanovich, E. U., & Rafiqovich, Z. A. (2023). Treatment of purulent-necrotic lesions of the lower extremities with modern drugs. Conferencea, 88-94.

Yusufjanovich, E. U., Rafiqovich, Z. A., & Irsalievich, E. K. (2023). Assessment of the Process of Epithelialization After Complex Treatment of Diabetic Foot Syndrome. Texas Journal of Medical Science, 16, 19-23.