Skip to main content
editor@theusajournals.com | Oscar Publishing Services Journal Home
Login

International Journal of Medical Sciences And Clinical Research

Peer Reviewed | Open Access | E-ISSN: 2771-2265
Published Article

COMPARATIVE ASSESSMENT OF ACUTE TOXICITY OF VINCANIN HYDROCHLORIDE DERIVATIVES IN RESEARCH CONDITIONS

COMPARATIVE ASSESSMENT OF ACUTE TOXICITY OF VINCANIN HYDROCHLORIDE DERIVATIVES IN RESEARCH CONDITIONS

Authors

  • Yu.R. Mirzaev
    Candidate Of Medical Sciences, Senior Scientific Researcher At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
  • T.T. Khamroev
    Basic Doctoral Student Of The Institute Of Plant Chemistry Named After S.Yu. Yunusov Of The Academy Of Sciences Of The Republic Of Uzbekistan
  • E.M. Ruzimov
    Junior Scientific Researcher At The S.Y. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
  • B.N. Khamdamov
    Basic Doctoral Student Of The Institute Of Plant Chemistry Named After S.Yu. Yunusov Of The Academy Of Sciences Of The Republic Of Uzbekistan
  • B.B. Abduazimov
    Senior Scientific Researcher At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
  • Sh.M. Adizov
    Phd, Senior Scientific Researcher At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
  • P.Kh. Yuldashev
    Ds Doctor Of Chemical Sciences, Professor At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
  • B.J.Elmuradov
    Ds Doctor Of Chemical Sciences, Professor At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan

DOI:

https://doi.org/10.37547/ijmscr/Volume02Issue10-03

Keywords:

Acute toxicity pyrazoline chloride pyrazoline iodine methylate

Abstract

This research paper presents the isolation of norfluorocurarine alkaloids from the Vinca erecta plant, substances with different chemical structures and the study of toxicological properties in various types of animals. Experiments have shown that mice are more resistant to the effects of pyrazoline chloride and pyrazoline iodide than rats. From the conducted studies, it can be concluded that it is advisable to carry out the biological activity of the studied substances to rats that are relatively immune to the action of these substances and this will allow further use of dosages that are relatively harmless to humans in various pathologies.