STUDY THE EFFECT OF YANTACIN ON SOME INDICATORS OF CELLULAR RENEWAL AND ON THE LEVEL OF PROTEIN EXPRESSION ON RAT HEPATOCYTES IN CHRONIC HELIOTRINE LIVER DAMAGE
Abstract
The effect of plant proanthocyanidin – yantacin isolated from the camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis in experimental conditions was studied. The studies were conducted on male rats with a body weight of 100 ±10 g. The effect of yantacin on the general and biochemical parameters of blood, as well as on p53, PCNA of liver tissue, mitotic and apoptotic index against the background of heliotrine liver damage was studied. As a result of the conducted studies, yantacin demonstrated a significant protective effect compared with the control group on the detected fibrosis, according to which certain indicators, against the background of chronic toxic liver damage. In this regard, a more extensive in-depth study of the protective and restorative effects of the studied plant proanthosianide substance on chronic changes in the liver, serious structural and functional disorders is being carried out.