International Journal of Medical Sciences And Clinical Research

International Journal of Medical Sciences And Clinical Research
ISSN: 2771-2265
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Articles | Open Access | https://doi.org/10.37547/ijmscr/Volume02Issue09-01

STUDY OF PSYCHOACTIVE ACTIVITY POTASSIUM SALT 5-(O-AMINOPHENYL)-1,3,4- OXADIAZOLE-2-THION (D-361)

S.Z. Rashidov , Junior scientific Researcher at the S.Y. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan
S.D. Rakhimboev , Basic doctoral student of the Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan
Z.I. Sanoev , PhD, Senior scientific Researcher at the S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan
I.T. Abdinazarov , Basic doctoral student of the Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan
T.T. Khamroev , Basic doctoral student of the Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan
D.S. Ismailova , PhD, Senior scientific Researcher at the S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan
B.J.Elmuradov , Ds Doctor of Chemical Sciences, professor at the S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan
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Published Date 2022-09-24
Pages 1-5
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    34

Abstract

These papers present a study of the synthetic compound potassium salt 5-(o-aminophenyl)-1,3,4-oxadiazol-2-thione (D-361) at doses of 10; 30 and 60 mg/kg by oral administration on motor activity, locomotor action of phenamine, haloperidol catalepsy and M-cholinergic receptors in experimental animals. Based on the results of the experiment, it was found that psychostimulating, partially dopamine-blocking, M-cholinergic blocking action.

Keywords

Potassium salt 5-(o-aminophenyl)-1,3,4-oxadiazol-2-thione, haloperidol, psychostimulant

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S.Z. Rashidov, S.D. Rakhimboev, Z.I. Sanoev, I.T. Abdinazarov, T.T. Khamroev, D.S. Ismailova, & B.J.Elmuradov. (2022). STUDY OF PSYCHOACTIVE ACTIVITY POTASSIUM SALT 5-(O-AMINOPHENYL)-1,3,4- OXADIAZOLE-2-THION (D-361). International Journal of Medical Sciences And Clinical Research, 2(09), 1–5. https://doi.org/10.37547/ijmscr/Volume02Issue09-01
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