This article analyzes, from a socio-philosophical perspective, the main factors influencing the transformation of personal culture under the conditions of the information society in New Uzbekistan. It examines the impact of the informatization process on the individual’s worldview, value system, communication culture, and skills of receiving and evaluating information. It also reveals the interrelationship of socio-economic, spiritual-moral, political-legal, cultural, information-communication, and personal-psychological factors. The article scientifically substantiates the acquisition of new content by personal culture in the context of the development of New Uzbekistan, as well as the specific features of its formation in the harmony of national and universal values.