A comprehensive investigation of vanadium (IV) and vanadium(V) coordination compounds with biologically relevant amino acid ligands, specifically glycine and glutamine, has been conducted. Four novel complexes were successfully synthesized and characterized through elemental analysis, infrared spectroscopy, ultraviolet-visible spectroscopy, and thermogravimetric analysis. The coordination behavior of these amino acids toward vanadyl (IV) and dioxovanadium(V) centers was systematically examined, revealing bidentate chelation through carboxylate and amino groups. Structural elucidation confirmed octahedral geometry for VO(II) complexes and distorted square pyramidal geometry for V(V) species. The antibacterial efficacy of synthesized complexes was evaluated against both Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacterial strains using disc diffusion and minimum inhibitory concentration (MIC) determination methods. Results demonstrated significantly enhanced antimicrobial activity of metal complexes compared to free ligands, with MIC values ranging from 12.5 to 50 μg/mL. The vanadium(V)-glutamine complex exhibited the most potent antibacterial activity, particularly against S. aureus (MIC = 12.5 μg/mL). These findings contribute to understanding vanadium-amino acid coordination chemistry and suggest potential applications in developing novel antimicrobial agents.

Vanadium complexes, amino acid ligands, glycine

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