This article discusses the synthesis of carboxymethyl chitosan from various molecules. The mass of chitosan, including low mass, has been determined in multivariate tests and averages 50–190 kDa, with a median size of 210–300 kDa and higher. Regarding antioxidant and moisturizing properties, carboxymethyl chitosan improved water solubility by 96%, 90%, and 89%, respectively. Natural chitosan resulted in the enhancement of the viscosity properties of carboxymethyl with higher molecular weight. As for the antioxidant properties, the radical scavenging activity values were 1.70 and 1.37 mg/mL, and thus the molecule had high antioxidant radical scavenging properties. Distilled water, propylene glycol, and pure Chitosan of three molecular weights have lower solubility and weaker antioxidant activity than carboxymethyl.

Selectivity, hyaluronic acid, titrimetry

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