The phenomenon of medication-related oral manifestations represents a significant and increasingly prevalent challenge in contemporary healthcare, particularly among patients with multiple comorbidities who require complex therapeutic regimens. The growing aging population, coupled with advances in medical treatment that allow patients with chronic conditions to live longer, has resulted in an unprecedented increase in polypharmacy practices, with approximately 40% of adults over 65 years taking five or more medications concurrently.

Drug-induced stomatitis, comorbid pathology, xerostomia

Abdullaev A.M. Clinical and morphological features of drug-induced lesions of the oral mucosa / A.M. Abdullaev, S.R. Karimova // Stomatology of Uzbekistan. – 2021. – № 3. – P. 15-22.

Akhmedov R.Kh. Pharmacological aspects of xerostomia development in patients with arterial hypertension / R.Kh. Akhmedov, N.U. Tursunova // Medical Journal of Uzbekistan. – 2020. – № 4. – P. 78-84.

Ismailov B.S. Comorbid pathology and risk of developing dental complications of pharmacotherapy / B.S. Ismailov // Clinical Pharmacology and Therapy. – 2019. – Vol. 28, № 2. – P. 45-51.

Karimova L.A. Diagnosis and treatment of drug-induced gingival hyperplasia / L.A. Karimova, M.R. Rakhimov // Periodontology. – 2021. – № 1. – P. 32-38.

Mamatkulov O.R. Prevention of drug-induced oral lesions in oncological patients / O.R. Mamatkulov, Z.I. Usmanova // Oncology and Radiology of Kazakhstan. – 2020. – № 3. – P. 67-73.

Norbekov Zh.M. Personalized approach to managing patients with polypharmacy in dental practice / Zh.M. Norbekov // New Day in Medicine. – 2021. – № 4. – P. 125-132.

Rakhimova D.N. Drug interactions and development of orofacial complications / D.N. Rakhimova, A.K. Yuldashev // Postgraduate Doctor. – 2019. – Vol. 97, № 6. – P. 28-35.

Salimov O.A. Integrated approach to prevention of dental complications in patients with diabetes mellitus / O.A. Salimov, Sh.B. Kadyrova // Endocrinology of Uzbekistan. – 2020. – № 2. – P. 89-96.

Al-Dwairi Z.N. Drug-induced oral reactions in patients with chronic diseases / Z.N. Al-Dwairi, M.A. Alsmadi // Int J Dent Hyg. – 2020. – Vol. 18, № 2. – P. 203-210.

Baek S.K. Drug-induced oral and dental adverse effects / S.K. Baek, H.J. Kim, Y.J. Lee // Hanyang Med Rev. – 2019. – Vol. 39, № 4. – P. 215-222.

Bascones-Martinez A. Oral manifestations of drug reactions / A. Bascones-Martinez, M. Figuero-Ruiz // Med Oral Patol Oral Cir Bucal. – 2019. – Vol. 24, № 3. – P. e321-e330.

Chen Y.W. Drug-induced oral lichenoid reactions: A systematic review / Y.W. Chen, M.Y. Lin, P.C. Yang // Oral Dis. – 2021. – Vol. 27, № 5. – P. 1099-1110.