The problem of chronic dyscirculatory encephalopathy (DCE) occupies one of the leading places in the structure of cerebrovascular pathology, determining high rates of morbidity, disability, and mortality in the population of middle-aged and elderly individuals. According to epidemiological studies, the prevalence of DEP in the general population is 2-8%, while with age, an exponential increase in morbidity is observed: from 1-2% in the 45-54 age group to 15-20% in individuals over 75. The modern concept of the pathogenesis of dyscirculatory encephalopathy is based on the understanding of the multifactorial nature of the disease, including vascular, metabolic, neurodegenerative, and neuroinflammatory mechanisms. Traditionally, researchers' main attention is focused on studying classical risk factors for cerebrovascular diseases: arterial hypertension, atherosclerosis, diabetes mellitus, dyslipidemia, and other somatic pathologies.

Prolonged adaptive stress, chronic dyscirculatory encephalopathy, cerebrovascular pathology

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