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THE ROLE OF CLOSTRIDIUM DIFFICILE IN THE DEVELOPMENT OF ANTIBIOTIC-ASSOCIATED DIARRHEA IN EARLY-AGED CHILDREN
Rabbimova Dilfuza Toshtemirovna , The head of the department of propaedutics of children's diseases, associate professor at Samarkand State Medical University, Uzbekistan Shavdirova Gulbonu Mansurovna , Doctoral student at the Department of propaedeutics of children's diseases at Samarkand State Medical University, UzbekistanAbstract
Interest in studying the problem of diarrhea in children is due to their wide distribution (1-1.2 billion cases per year worldwide according to WHO, 2010), polyetiology, difficulty of differential diagnosis and tendency to acute and chronic course. In recent years, foreign and domestic authors have attached increasing importance to the so-called antibiotic-associated diarrhea (AAD), components: 6-40% in the structure of intestinal diseases. In the etiological structure of AAD in young children, the share of C.difficile infection was 47%. A rusk factor for development is also combination therapy with antibiotics.
Keywords
Clostridium difficile, antibiotic-associated diarrhea, young children
References
Van Boeckel TP, Gandra S, Ashok A, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis, 2014, 14: 742-50.
Turnbaugh PJ, et al. An obesity-associated gut microbiome with inceased capacityfor energy harvest. Nature, 2006, 444: 1027-1031.
3. Marrs T, Flohr C. How do Microbiota Influence the Development and Natural History of Eczema and Food Allergy? The Pediatric Infectious Disease Journal, 2016 November, 35(11): 1258-1261.
Barakat Maha, El-Kady Zeinab, Mostafa Mohamed, Naglaa Ibrahim and Hamdy Ghazaly. Antibiotic-associated Bloody Diarrhea in Infants: Clinical, Endoscopic and Histopathoogic Profiles. JPGN, Jan 2011, 52(1).
Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea. A Systematic Review and Meta-analysis. JAMA, 2012 May 9, 307(18).
Лузина, Е. В. Ассоциированная с антибиотиками диарея в клинической практике / Е. В. Лузина, Н. В. Ларева // Терапевтический архив. - 2013. - № 2. - С. 85-88.
Mechanisms and Management of Antibiotic-Associated Diarrhea / C. Hogenauer, H. F. Hammer, G. J. Krejs (et al.) // Clinical Infectious Diseases. - 1998. -Vol. 27, № 4. - P. 702-710.
Распространенность Clostridium dificile-ассоциированной диареи у госпитализированных больных (результаты российского проспективного многоцентрового исследования) / Н. В. Дмитриева, Г. А. Клясова, Н. В. Бакулина (и др.) // КМАХ. - 2017. - Т. 19, № 4. - С. 268-274.
Asempa, T. E. Clostridium difficile infection in the elderly: an update on management / T. E. Asempa, D. P. Nicolau. // Clinical Interventions in Aging. - 2017. -Vol. 12. - Р. 1799-1809.
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Copyright (c) 2024 Rabbimova Dilfuza Toshtemirovna , Shavdirova Gulbonu Mansurovna
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