This article analyzes the clinical course of acute pneumonia in young children, the pathogenetic significance of the level of endotoxemia, and the effectiveness of complex pharmacotherapy approaches. It is scientifically proven that an increase in endotoxin load is closely related to the exacerbation of the inflammatory process, intoxication syndrome, respiratory failure, and microcirculatory disorders. The study evaluated laboratory parameters, inflammatory mediators, and metabolic changes, and developed differential treatment methods depending on the level of endotoxemia. The complex pharmacotherapy included antibacterial, detoxification, inflammation-controlling, antioxidant, and symptomatic treatment methods. The results obtained showed that individualization of therapy taking into account the endotoxemia factor accelerates clinical recovery, reduces the risk of complications, and accelerates the regression of infiltrative processes in the lungs.

Acute pneumonia, endotoxemia, early childhood

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