Interleukin-10 (IL-10) is a key immunoregulatory cytokine that plays an important role in anti-inflammatory and immunosuppressive processes in the body. Objective:This study aims to investigate the association of single nucleotide polymorphism (SNP) c. -1082G>A of the IL10 gene promoter located in the 1q31-32 locus of the first human chromosome with inflammatory and ulcerative lesions of the stomach. Material and methods. The study included 96 unrelated patients of the Uzbek population with inflammatory and ulcerative diseases of the stomach, including: 18 patients with chronic atrophic gastritis, 13 with chronic erosive gastritis and 55 with gastric ulcer. Conclusion. It is assumed that the homozygous AA genotype (c. -1082G>A, rs1800896) of the IL10 gene may be associated with the development of inflammatory and ulcerative gastric lesions, which may be due to reduced production of the anti-inflammatory cytokine IL-10. Further studies with a larger sample are needed to confirm this hypothesis.

SNP, c. polymorphism. -1082G>A of the IL10 gene, rs1800896

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