Connective tissue dysplasia (CTD) is a genetically determined disorder associated with impaired synthesis and structure of collagen, elastin, and other components of the extracellular matrix. Children with CTD are at high risk of developing nutritional deficiencies that aggravate structural and functional disorders of connective tissue. This review analyzes modern approaches to assessing and correcting nutritional status in pediatric CTD, emphasizing evidence-based nutritional, metabolic, and nutraceutical interventions. Individualized correction of protein, vitamin, and trace element deficiencies significantly improves metabolic balance, functional adaptation, and quality of life in affected children.

Connective tissue dysplasia, children, nutritional status

Surkova, E. V., & Romanov, A. E. (2022). Connective tissue dysplasia in children: Modern approaches to diagnosis and therapy. Pediatrics, 101(5), 42–48.

Kovalenko, T. V., Makarova, L. A., & Petrov, I. N. (2023). Nutritional interventions in pediatric connective tissue dysplasia. Nutrients, 15(1), 122–130.

Melmed, S., Polonsky, K. S., & Larsen, P. R. (2020). Nutritional management in connective tissue disorders. Clinical Nutrition, 39(2), 387–395.

Rybakova, E. N., & Sokolova, N. A. (2024). Nutritional support in pediatric genetic connective tissue diseases. Frontiers in Pediatrics, 12, 1156.

Khadzhieva, A. I., & Fedorova, I. A. (2020). Vitamin and mineral support in connective tissue dysplasia in children. Russian Journal of Pediatrics, 9(3), 55–61.

Nguyen, L., et al. (2022). Gut microbiota modulation in connective tissue disorders: Therapeutic implications. Nutrients, 14(6), 1245.

Nikitina, N. A., & Zubkova, I. E. (2021). Amino acid supplementation in the management of hereditary connective tissue disorders. Clinical Pediatrics, 8(4), 23–29.

El-Khatib, F. F., & Al-Khawaja, R. (2023). Role of vitamin D and magnesium in pediatric connective tissue health. Journal of Clinical Nutrition and Metabolism, 7(3), 98–106.

Ranganathan, S., et al. (2020). Nutraceuticals in pediatric metabolic and connective tissue disorders: An evidence-based review. Nutraceutical Research, 8(2), 88–97.

Fedorov, V. M., et al. (2021). Pathophysiological basis of nutritional therapy in connective tissue dysplasia. Therapeutic Archive, 93(4), 32–39.

World Health Organization (WHO). (2023). Nutritional status assessment in pediatric populations: WHO guidelines. Geneva: WHO Press.

Pleshkov, S. S., & Ivanova, L. R. (2022). The role of probiotics in children with genetic connective tissue disorders. Journal of Pediatric Gastroenterology and Nutrition, 74(5), 901–909.

Kovacs, L., & Toth, A. (2021). Micronutrient metabolism in hereditary connective tissue disorders. European Journal of Pediatrics, 180(9), 2857–2865.

Bartsch, R., et al. (2024). Nutritional modulation of collagen metabolism: Clinical perspectives. International Journal of Molecular Sciences, 25(3), 1345.

Zhang, Y., & Lin, X. (2025). Nutrigenomics in pediatric connective tissue diseases: Emerging concepts. Nutrients, 17(2), 211.