The article is devoted to the analysis of the role of leptin and other adipokines in the regulation of hematopoiesis. It is shown that bone marrow adipose tissue is an active component of the hematopoietic niche and affects the maintenance, proliferation and differentiation of stem and progenitor blood cells. Leptin and its receptor provide the production of key factors SCF and CXCL12 by mesenchymal stromal cells. Adiponectin and resistin are involved in modulating hematopoietic recovery after myelosuppression. Impaired adipokine secretion in obesity, aging, and malignant processes leads to niche dysfunction and changes in hematopoiesis efficiency. Understanding the molecular mechanisms of adipokine action opens up opportunities for developing new therapeutic approaches.

Leptin, adipokines, adiponectin

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