Articles | Open Access | https://doi.org/10.37547/ijmscr/Volume05Issue09-09

Therapeutic Outcomes Of Enzyme Replacement In Patients With Chronic Pancreatitis

Khamraev A. Abror , Tashkent State Medical University, Tashkent, Republic of Uzbekistan
Aripova N. Nargiza , Tashkent State Medical University, Tashkent, Republic of Uzbekistan
Rakhmatova R. Markhabo , Bukhara State Medical Institute, Named After Abu Ali Ibn Sino of Uzbekistan
Oydinova Munavvar , Tashkent State Medical University, Tashkent, Republic of Uzbekistan

Abstract

In chronic pancreatitis, increased levels of vitamin 25-OH-D deficiency are associated with concomitant risk factors in patients, the course of the disease, the degree of pancreatic fibrosis and calcification, impaired digestion and absorption of macro- and micronutrients due to a decrease in its exocrine function, which requires the development of effective approaches to treatment and prevention, as well as the development of long-term enzyme therapy to improve quality of life. The article below is devoted to the importance of enzyme therapy in the course of chronic pancreatitis.

Keywords

Hypovitaminosis D, chronic pancreatitis, enzyme therapy, steatorrhea

References

Bideyeva T.V., Andreyev D.N., Kucheryavyy YU.A., Mayev I.V. Dinamika urovnya vitamina D u bol'nykh khronicheskim pankreatitom na fone zamestitel'noy fermentnoy terapii //Meditsinskiy sovet. - 2019. - №3. – C. 156-160.

Yegshatyan L.V., Dudinskaya Ye.N., Tkacheva O.N., Kashtanova D.A. Rol' vitamina D v patogeneze khronicheskikh neinfektsionnykh zabolevaniy. // Osteoporoz i osteopatii. - 2014. - T. 17, №3. - S. 27-30.

Zazerskaya I.Ye. i dr. Vitamin D i reproduktivnoye zdorov'ye zhenshchiny. // SP b: OOO ‘Eko-Vektor’, 2017.- 151 s

Ivashkin V.T., Mayev I.V., Okhlobystin A.V. i dr. Rekomendatsii Rossiyskoy gastroenterologicheskoy assotsiatsii po diagnostike i lecheniyu khronicheskogo pankreatita. // Ros. zhurn. gastroenterol., gepatol., koloproktol. - 2014. - T. 24 №4. - S. 70–97.

Kulikov V.A., Grebennikov I.N. Rol' vitaminov D i K v razvitii sosudistoy kal'tsifikatsii i ateroskleroza // Vestnik VGMU. - 2012. - T. 11, №4. - S. 5-14

Duggan S.N., Smyth N.D., Murphy A. et al. High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis. // Clin. Gastroenterol. Hepatol. 2014; 12: 219-228.

Frick T.W. Нerole of calcium in acute pancreatitis. // Surgery. 2012; 152: 157-163.

Gromova O.A., Torshin I.Yu., Pronin A.V., Rudakov K.V. Systematic analysis of neurological roles and prospects for the use of vitamin D for the prevention and treatment of cerebrovascular and demyelinating diseases // Neurology and psychiatry named after S.S. Korsakov. 2014; 12: 57-61.

Han Z., Margulies S.L., Kurian D., Elliott M.S. Vitamin D Deficiency in Patients with Pancreatitis: Is Vitamin D Replacement Required? // Pancreat Disord Ther. 2016. 172 (6).

Kunovsky L, Dite P, Jabandziev P, et al. Causes of exocrine pancreatic insufficiency other than chronic pancreatitis. //J Clin Med. 2021; 10: 5779.

Kusakabe J, Anderson B, Liu J, et al. Long-term endocrine and exocrine insufficiency after pancreatectomy. //J Gastrointest Surg. 2019; 23: 1604–1613.

Rakhimberdiyeva Z., Ganievich M., Targeted M. Cancer Therapy: Leveraging Dual pH-Sensitive Polymers Nanoparticles for Doxorubicin Delivery and Tumor Suppression: A Review. J Nanostruct, 2024; 14(1):204-213. DOI: 10.22052/JNS.2024.01.021

Syman, K. , Uazhanova, R. , Suleimenova, Z. , Rasulovna, R. M. , Xamdamova, ,. E. , Sabirovich, K. U. , Esanmurodova, N. , Shichiyakh, R. , Kamiljanovna, S. N. , Abdullayevna, N. S. , Khurramovna, S. S. , Narbutaev, K. B. and Menglikulov, B. (2024). Comprehensive analysis of amino acid profile in camel milk: Implications for nutrition and sustainable development. Caspian Journal of Environmental Sciences, 22(5), 1055-1064. doi: 10.22124/cjes.2024.8070

Schwartz G.Y. Vitamin D and D-hormone. Moscow: Anacharsis, 2005. 152 p. (in Russian).

Wacker M., Holick M.F. Vitamin D — effects on skeletal and extraskeletal health and the need for supplementation. // Nutrients. 2013; 10 (1): 111-148.

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Khamraev A. Abror, Aripova N. Nargiza, Rakhmatova R. Markhabo, & Oydinova Munavvar. (2025). Therapeutic Outcomes Of Enzyme Replacement In Patients With Chronic Pancreatitis. International Journal of Medical Sciences And Clinical Research, 5(09), 51–55. https://doi.org/10.37547/ijmscr/Volume05Issue09-09