This study evaluates the clinical effectiveness of ECG telemetry technology in the early diagnosis and prevention of myocardial infarction in patients with acute coronary syndrome (ACS) in the Fergana region. A total of 48 patients who contacted the ambulance due to chest pain were included. Each patient underwent an ECG examination at the site of the call, with the results transmitted in real-time to regional or national cardiologists via telemetry. ST-segment elevation was detected in all cases, and patients were promptly referred to specialized cardiology centers for coronary angiography and stenting within an average of 2.2 ± 1.1 hours. Statistical analysis revealed that none of the patients developed myocardial infarction, disability, or death (0%). Most of the patients were male (77.1%) and over the age of 60 (54.2%). Hypertension was present in 100% of patients, followed by obesity (56.3%), smoking (39.6%), hereditary predisposition (27.1%), and diabetes mellitus (12.5%). The results highlight the high preventive value of ECG telemetry in managing ACS, especially among high-risk groups. The integration of digital diagnostics with a coordinated ambulance system significantly improved clinical outcomes and demonstrates the potential for widespread implementation in regional emergency response systems.