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International Journal of Medical Sciences And Clinical Research

Peer Reviewed | Open Access | E-ISSN: 2771-2265
Published Article

Current Course of Antibiotic-Associated Diarrhea in Children

Current Course of Antibiotic-Associated Diarrhea in Children

Authors

  • Kholmamatova U.S.
    Andijan State Medical Institute, Uzbekistan
  • Usmanova E.M.
    Andijan State Medical Institute, Uzbekistan

DOI:

https://doi.org/10.37547/ijmscr/Volume06Issue09-02

Keywords:

Antibiotic-associated diarrhea intestinal microbiocenosis dysbiosis

Abstract

Antibiotic-associated diarrhea (AAD) remains a pressing issue in pediatrics due to the high prevalence of antibacterial therapy and a significant risk of intestinal microbiocenosis disorders in children. The aim of the study was to study the clinical and laboratory indicators of intestinal microbiocenosis changes in children with antibiotic-associated diarrhea.

61 children aged 2 months to 5 years with confirmed antibiotic-associated diarrhea were under observation. The study was conducted at the Andijan Regional Infectious Diseases Hospital. Statistical processing of the results was carried out using the Statistica 6.0 program using the non-parametric Mann-Whitney criterion. It was established that the majority of AAD cases were registered in children aged 1 to 7 years (81.2%). The disease most frequently developed after the use of combined antibacterial therapy (40.9%) and III-IV generation cephalosporins (19.7%). In the clinical structure, gastroenteritis predominated (55.8%), while enterocolitis (31.1%) and hemocolitis (13.1%) occurred less frequently. The majority of patients had a moderate course of the disease (90.1%). The connection between the development of AAB and the severity of dysbiotic intestinal disorders against the background of the inflammatory process and antibacterial therapy has been identified. The highest incidence of antibiotic-associated diarrhea was observed in respiratory and intestinal infections departments.

The results obtained indicate the significant role of intestinal microbiocenosis disorders in the development of antibiotic-associated diarrhea in children and confirm the need for the rational use of antibacterial drugs, as well as timely prevention and correction of intestinal dysbiotic changes.

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