Skip to main content
editor@theusajournals.com | Oscar Publishing Services Journal Home

International Journal of Medical Sciences And Clinical Research

Peer Reviewed | Open Access | E-ISSN: 2771-2265
Published Article

A Study Of Some Complications Of Type 1 Diabetes Mellitus In Children And Adolescents Receiving Conventional Versus Basal Bolus Insulin Therapy

A Study Of Some Complications Of Type 1 Diabetes Mellitus In Children And Adolescents Receiving Conventional Versus Basal Bolus Insulin Therapy

  • Rand Hadi Kareem
    M.B.Ch.B. Iraqi board of medical specializations, Iraq
  • Rebee Mohsin Hasani
    Assistant Professor / Babylon University College of medicine C.A.B.P., F.I.C.M.S, Consultant paediatrician, Iraq
  • Shawq Alaa Jabir
    FIBMS paediatrics, Endocrinology, Iraq
Type1 Diabetes Mellitus Insulin Regimen Diabetic Ketoacidosis

Background: Diabetes Mellitus type 1 is a common chronic disorder in childhood and adolescence. In type 1 diabetes, insulin therapy is life saving. There are two insulin regimens, conventional and basal bolus, change in the type of regimen to reduce and maintain glycated hemoglobin, with relative risk reduction of attacks of hypoglycemia, diabetic ketoacidosis, microvascular and macrovascular complications.

 

Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014 Jan 4;383(9911):69–82.

Patterson CC, Harjutsalo V, Rosenbauer J, Neu A, Cinek O, Skrivarhaug T, et al. Trends and cyclic variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989–2013: a multicentre prospective registration study. Diabetologia. 2019 Mar;62(3):408–17.

Chiang JL, Maahs DM, Garvey KC, Hood KK, Laffel LM, Weinzimer SA, et al. Type 1 diabetes in children and adolescents: a position statement by the American Diabetes Association. Diabetes Care. 2018 Sep;41(9):2026–44.

The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993 Sep 30;329(14):977–86.

Silverstein J, Klingensmith G, Copeland K, Plotnick L, Kaufman F, Laffel L, et al. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care. 2005 Jan;28(1):186–212.

Danne T, Phillip M, Buckingham BA, Jarosz-Chobot P, Saboo B, Urakami T, et al. ISPAD Clinical Practice Consensus Guidelines 2018: insulin treatment in children and adolescents with diabetes. Pediatr Diabetes. 2018 Oct;19 Suppl 27:115–35.

Svoren BM, Volkening LK, Butler DA, Moreland EC, Anderson BJ, Laffel LM. Temporal trends in acute complications in type 1 diabetes: the potential role of changes in treatment and utilization of care. Pediatr Diabetes. 2007 Apr;8(2):103–9.

Shah AS, Riddell MC, Lovblom LE. Intensive insulin therapy and glycemic control in children with type 1 diabetes: a review of current strategies. Curr Diab Rep. 2021;21(10):49.

Chou WY, Weng WC, Lee CH, Wu SC, Lin JD. Association of diabetic ketoacidosis, severe hypoglycemia and glycemic control among children and young adults with type 1 diabetes mellitus treated with premixed versus basal-bolus insulin therapy. Biomed J. 2018;41(6):348-55.

Franchini S, Scaramuzza A, Bonfanti R, Lombardi G, Meschi F, Chiarelli F, et al. Hypoglycemia in children with type 1 diabetes: unawareness is a concrete risk. Curr Med Res Opin. 2016;32(9):1487-91.

Alabedi RF. Comparative study between multiple daily injections and conventional insulin regimens in Iraqi children and adolescents with type 1 diabetes mellitus. Ann Trop Med Public Health. 2020;23(12).

Saboo B. Key elements of successful intensive therapy in patients with type 1 diabetes. Indian J Endocrinol Metab. 2015;19(Suppl 1)

Lind M, Polonsky W, Hirsch IB, Heise T, Bolinder J, Dahlqvist S, et al. Continuous glucose monitoring vs conventional therapy for glycemic control in adults with type 1 diabetes treated with multiple daily insulin injections: the GOLD randomized clinical trial. JAMA. 2017;317(4):379-87.